Results 171 to 180 of about 238,736 (311)

The Determinants of the Willingness to be an Organ Donor [PDF]

open access: yes
The total value of life lost due to death because of waiting for an organ transplant is greater than $4 billion annually in the United States, and the excess demand for organs has been increasing over time.
Erdal Tekin, Naci Mocan
core  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Beyond donor eligibility: nutritional and lifestyle heterogeneity and implications for long-term donor health preservation. [PDF]

open access: yesFront Nutr
Mazza E   +10 more
europepmc   +1 more source

30 Eye’ll Follow You’: tracking distributed corneal tissue from the eye bank of Melbourne, Australia

open access: yesBMJ Open Ophthalmology
Gavin DeLoree   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Blood Donation Deferral at a Tertiary Centre in Riyadh: Epidemiology, Sex-Specific Patterns, and Donor Retention Outcomes. [PDF]

open access: yesJ Clin Med
Oraijah N   +10 more
europepmc   +1 more source

8 Bugs in the eye bank. A five-year risk assessment of microbial contamination in the Melbourne eye bank

open access: yesBMJ Open Ophthalmology
Gavin DeLoree   +4 more
doaj   +1 more source

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