Results 211 to 220 of about 601,176 (342)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intensive Care to Facilitate Organ Donation: Insights From the French Guidelines. [PDF]

Transpl Int
Le Dorze M, Armand A, Charpentier J, Humbertjean L, Zuber B.   +4 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Results of Kidney Transplantation from Donors Following Euthanasia in the Netherlands: Benchmarking Science and Ethical Challenge

Transplant International
Nichon E. Jansen, Dale Gardiner
doaj   +1 more source

Nurses' attitudes and knowledge about organ donation and transplantation in closed hospital wards. [PDF]

J Crit Care Med (Targu Mures)
Tzenalis A, Kontesidou E, Kipourgos G, Andreopoulou E, Gkotsi A, Albani E.   +5 more
europepmc   +1 more source

The Effects of Product Type and Donation Magnitude on Willingness to Pay More for a Charity‐Linked Brand

, 1999
Michal Strahilevitz
openalex   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

« Monsieur graine, donneur, mais pas papa » : Le travail narratif des mères seules par don

Enfances, Familles, Générations
Research Framework: The concept of personal origins is constantly evolving as the ways in which families are formed diversify. In France, parents who have recourse to sperm donation are now encouraged to pass on to their child the circumstances of their ...
Margot Lenouvel
doaj  

To give or not to give, and to whom?-These are the questions! Determinants of selective organ donation intentions. [PDF]

Front Psychol
Cobzeanu A, Opariuc-Dan C, Merlici IA, Cobzeanu BM, Tanase I.   +4 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source