Results 351 to 360 of about 655,937 (417)

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Organ donation in Germany: opt-in vs. opt-out-opinions and voting patterns in the 19th German Bundestag. [PDF]

Front Transplant
Zeybek A, Le NS, Settmacher U, Koch M, Arbogast H, Ziganshyna S, Hahnenkamp K, Nashan B.   +7 more
europepmc   +1 more source

MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer

Molecular Oncology, Volume 19, Issue 4, Page 1188-1202, April 2025.
Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara, Rosalia Battaglia, Angela Caponnetto, Anna Fazzio, Michele Stella, Cristina Barbagallo, Nicolò Musso, Federica Lunelio, Maria Elena Vento, Placido Borzì, Paolo Scollo, Davide Barbagallo, Marco Ragusa, Salvatore Pernagallo, Cinzia Di Pietro   +14 more
wiley   +1 more source

Evaluating Risk in Kidney Living Donors. [PDF]

Transpl Int
Ortiz F, Marson L, Thomas R, Kousios A, Rista E, Lefaucheur C, Cimen S, Cucchiari D, Zaza G, Furian L, Akin B.   +10 more
europepmc   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, Volume 19, Issue 5, Page 1508-1516, May 2025.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

Psychosocial Determinants of Living Kidney Donors: A Cross-Sectional Study. [PDF]

Risk Manag Healthc Policy
Alumran A, Aljanoubi EH, Bureqa AS, Alturki R, Alrayes SA, Alakrawi Z, Alshakhs F, Aljuwair M.   +7 more
europepmc   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Donor-Related Risk Factors for Normothermic Machine Perfusion in Liver Transplantation: A Meta-Analysis. [PDF]

Liver Int
den Dekker AMP, Franssen A, Steyerberg EW, Lam HD, Doppenberg JB, Alwayn IPJ.   +5 more
europepmc   +1 more source

Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

Molecular Oncology, Volume 19, Issue 4, Page 1002-1028, April 2025.
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch, Sara Sánchez‐Serra, Marta Rosàs‐Lapeña, Nicolás Costa‐Fraga, Judit Besalú‐Velázquez, Janet Illa‐Bernadí, Silvia Mateo‐Lozano, Florencia Cidre‐Aranaz, Thomas G.P. Grünewald, Ángel Díaz‐Lagares, Roser Lopez‐Alemany, Òscar M. Tirado   +11 more
wiley   +1 more source

(Pro)renin, Erythropoietin, Vitamin D and Urodilatin Release From Human Donor Kidneys During Normothermic Machine Perfusion: Predictors of Early Post-Transplant Outcome? [PDF]

Clin Transplant
Lin H, Bousnina K, Slagter JS, Fang Y, Cristoferi I, Garrelds IM, Danser AHJ, Reinders MEJ, Minnee RC, Hoogduijn MJ.   +9 more
europepmc   +1 more source