Results 171 to 180 of about 44,178 (276)

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

open access: yesAdvanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song   +12 more
wiley   +1 more source

The Donkey Genome: From Evolutionary Insights to Sustainable Breeding Strategies. [PDF]

open access: yesAnimals (Basel)
Zhu Q   +8 more
europepmc   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

Absence of Host-Specific Hemotropic Mycoplasmas in Horses and Donkeys from Croatia: First Systematic Survey in Southeastern Europe. [PDF]

open access: yesAnimals (Basel)
Konstantinović N   +14 more
europepmc   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

open access: yesAdvanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin   +13 more
wiley   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao   +12 more
wiley   +1 more source

How Fine-Grained is Reality? [PDF]

open access: yes, 2017
Fritz, Peter
core  

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