Results 71 to 80 of about 57,527 (332)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Fault tree analysis and prevention strategies for gas explosion in underground coal mines of Pakistan [PDF]
, 2019 Purpose. Gas explosion in the underground coal mines of Pakistan is the main source of coal miners’ mortalities. The purpose of this article is to analyze the main causes of gas explosion in the underground coal mines of Pakistan. Methods.
Ali, M +7 more
core +2 more sources
Anesthetic impact assessment of nefopam, xylazine, ketamine, propofol combination in local donkeys
SVU-International Journal of Veterinary Sciences, 2023 Anesthesia is used in animals to relieve pain during surgical interference or other procedures which were likely causing pain. Safe, effective, and reversible anesthesia requires selecting proper anesthetic agents.
Khaled M. Abdelbasset +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Development of a Donkey Grimace Scale to Recognize Pain in Donkeys (Equus asinus) Post Castration
Animals, 2020 Simple Summary Donkeys originally evolved as a desert animal, and unlike the horse (which flees or runs away from danger), the donkey fights to avert danger. Hence, donkeys are more stoic and tend to express fear, pain, and discomfort in more subtle ways
Emma K Orth +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Transrectal ultrasonography of the adrenal glands in donkeys (Equus asinus) [PDF]
, 2016 Little information is available for medical imaging in donkeys and no report about adrenal glands ultrasonography can be found in scientific literature. The feasibility of transrectal ultrasonography of the adrenal glands was tested on 30 healthy donkeys
Cerquetella, Matteo +6 more
core +1 more source
Frontiers in Veterinary Science, 2020 Non-governmental organizations (NGOs) work across the globe to improve the welfare of working equids. Despite decades of veterinary and other interventions, welfare issues persist with equids working in brick kilns.
T. Watson +5 more
semanticscholar +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source