Results 231 to 240 of about 1,816,290 (304)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of Vascular Anastomosis Time on Kidney Transplant Outcomes - A Systematic Review. [PDF]

Transpl Int
Sayah K, Burt H, Zheng Y, Lee T, Yuen L, Nahm C, Yao J, Lim W, Wong G, Lee L, Hameed A, Pleass H.   +11 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differences in Mortality by Donor Sex and Age in a Multinational Cohort of Liver Transplant Recipients. [PDF]

Transplant Direct
Grinspan LT, Zhang X, Dahhou M, Süsal C, Döhler B, Melk A, Vinson A, Foster BJ.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Stimulus-Responsive Perselenide, Thioselenide, and Selenosulfide Donors for Reactive Selenium Species Chemical Biology. [PDF]

J Am Chem Soc
Tripathi R, Hankins RA, Yi J, Liu L, Presti RS, Cohen MH, Sawase LR, Luna TD, Ding W, Lukesh JC.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Kaposi Sarcoma-Associated Herpesvirus Infection and Complications Among Solid Organ Transplant Recipients - United States, January 2021-September 2025. [PDF]

MMWR Morb Mortal Wkly Rep
Kracalik I, Annambhotla P, McCormick DW, Geller AI, McDavid K, Griffin I, Lynch R, Doby B, Natori Y, Tokman S, Durand CM, Kotton CN, Blumberg E, La Hoz RM, Hicks LA, Pouch SM, Basavaraju SV, Donor-Derived KSHV Investigation Group.   +17 more
europepmc   +1 more source

Donor Experience and Satisfaction: A Cross-Sectional Survey of Australian Milk Donors. [PDF]

Matern Child Nutr
Newman C, Hyde MK, Edwards AR, Clifford V, Masser BM, Klein LD.   +5 more
europepmc   +1 more source