Results 251 to 260 of about 3,804,425 (381)

FACTORS FOR DE-SELECTION OF POTENTIAL CANDIDATES FOR LIVER DONOR LIVER TRANPLANT IN A TETIARY CARE HOSPITAL

, 2020
Anum Abbas, Rabia Tariq, Aimen Abbas, Ehtesham Haider, Farrukh Saeed   +4 more
openalex   +1 more source

Graft selection strategy in adult‐to‐adult living donor liver transplantation: When both hemiliver grafts meet volumetric criteria [PDF]

, 2016
Wuttiporn Manatsathit, Hrishikesh Samant
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

High-Throughput Screening Assay for Convalescent Sera in COVID-19: Efficacy, Donor Selection, and Variant Neutralization. [PDF]

Microorganisms
Kota KP, Trakht I, Kalantarov G, Ordonez D, Wei J, Trefry S, Bavari E, Richardson J, Zamani R, Raney C, Nasar F, Daugherty B, Lederman S, Bavari S.   +13 more
europepmc   +1 more source

Optimizing Haploidentical Transplant for Adults with Acute Lymphoblastic Leukemia: The Role of Donor and Graft Selection. a Study from the ALWP of the EBMT [PDF]

Jaime Sanz, Allain Thibeault Ferhat, Anna Maria Raiola, Didier Blaise, Mutlu Arat, Yener Koç, Malek Benakli, Mi Kwon, Alexander Kulagin, Matteo Parma, Simona Sica, Johanna Tischer, Jiří Pavlů, Nathalie Dhédin, Giovanni Grillo, Nicolaus Kröger, Sebastian Giebel, Simona Piemontese, Mohamad Mohty, Fabio Ciceri   +19 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A New Tool Supporting the Selection of the Best Hematopoietic Stem Cell Donor by Modelling Local Own Real-World Data

Roberto Crocchiolo, Stefania Cacace, Giuseppe Milone, Barbara Sarina, Alessandra Cupri, Salvatore Leotta, Giulia Giuffrida, Andrea Spadaro, Jacopo Mariotti, Stéfania Bramanti, Alice Fumagalli, Maria Pia Azzaro, Sebastiana Toscano, Quirico Semeraro   +13 more
openalex   +2 more sources

RED BLOOD CELL (RBC) TRANSFUSION FOR PATIENTS HAVING ALLOANTIBODIES AND AUTOANTIBODIES: SELECTION OF APPROPRIATE DONOR BLOOD AND EFFICACY OF ALLOANTIGEN-MATCHED RBCS TRANSFUSION

, 2007
Hiroyasu Yasuda, Miho Okutsu, Kinuyo Kawabata, Saori Miura, Chikako Baba, Satoshi Ono, Yoko Gunji, Kazuya Watanabe, Yuko Obata, Ryoko Kikuchi, Hitoshi Ohto   +10 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source