Results 71 to 80 of about 584,120 (299)

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo [PDF]

, 2007
We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene transfer. Those with sufficient follow-up were found to have recovered substantial immunity in the absence of any serious adverse events up to 5 years after treatment.
Kerstin Schwarzwaelder, Steven J. Howe, Manfred Schmidt, Martijn H. Brugman, Annette Deichmann, Hanno Glimm, Sonja Schmidt, Claudia Prinz, Manuela Wissler, Douglas J.S. King, Fang Zhang, Kathryn L. Parsley, Kimberly C. Gilmour, Joanna Sinclair, Jinhua Bayford, Rachel Peraj, Karin Pike-Overzet, Frank J.T. Staal, Dick de Ridder, Christine Kinnon, Ulrich Abel, Gerard Wagemaker, H. Bobby Gaspar, Adrian J. Thrasher, Christof von Kalle, Cavazzana-Calvo, Gaspar, Hacein-Bey-Abina, Aiuti, Aiuti, Gaspar, Ott, Hacein-Bey-Abina, Li, Kustikova, Modlich, Montini, Mitchell, Schröder, Wu, Bushman, Schmidt, Schmidt, Hematti, Laufs, Suzuki, Bartholomew, Recchia, Calmels, Hoeben, Palmer, Xu, Dik, Ge   +53 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Outcomes of lung transplants utilizing donors from outside the continental United States

JHLT Open
Background: Efforts to expand the lung transplant donor pool have included re-evaluating geographic restrictions and accepting longer distances between donor and recipient centers. We evaluated the use of organs from donors outside the continental United
Reed T. Jenkins, MD, Emily L. Larson, MD, Alice L. Zhou, MD, Jessica M. Ruck, MD, PHD, David J. Farhat, MD, Helene Rached, DO, Al-Faraaz Kassam, MD, MBA, Christian A. Merlo, MD, Ramon A. Riojas, MD, Errol L. Bush, MD   +9 more
doaj   +1 more source

Theory of resonance energy transfer involving nanocrystals: the role of high multipoles

, 2007
A theory for the fluorescence resonance energy transfer (FRET) between a pair of semiconducting nanocrystal quantum dots is developed. Two types of donor-acceptor couplings for the FRET rate are described: dipole-dipole (d-d) and the dipole-quadrupole (d-
Abramowitz M., Efros A. L., Eran Rabani, Mukamel S., Roi Baer   +4 more
core   +1 more source

Short-period AM CVn systems as optical, X-ray and gravitational wave sources [PDF]

, 2003
We model the population of AM CVn systems in the Galaxy and discuss the detectability of these systems with optical, X-ray and gravitational wave detectors.
Bath, Bildsten, Boissier, Cooray, Cropper, Driebe, Evans, Faulkner, Fedorova, G. Nelemans, Hakala, Han, Hansen, Hellings, Hils, Hoare, Hurley, Iben, Israel, Israel, Jha, Kato, Kippenhahn, Klypin, Kroupa, L. R. Yungelson, Larson, Marsh, Marsh, Mauche, Miller, Morrison, Motch, Muno, Nelemans, Nelemans, Nelemans, Nelemans, Norton, Paczynski, Podsiadlowski, Pols, Portegies Zwart, Predehl, Pringle, Pringle, Ramsay, Ramsay, Ramsay, Rezzolla, Ruiz, S. F. Portegies Zwart, Sandage, Solheim, Strohmayer, Thorstensen, Townsley, Tsugawa, Tutukov, Tutukov, Tutukov, Ulla, Van Teeseling, Van Teeseling, Verbunt, Vila, Wade, Wang, Warner, Warner, Webbink, Webbink, Wood, Woudt, Woudt, Wu, Yoon, Zapolsky   +77 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Title: allogeneic peripheral blood stem cell transplantation for Myeloid sarcoma: a single-center experience

Hematology
Background Myeloid sarcoma (MS) is a rare extramedullary manifestation of myeloid neoplasms and usually has poorer outcomes than acute myeloid leukemia without extramedullary disease.
Dewan Zhao, Wenbin Cao, Gang Li, Ying Zhang, Xiaohui Zheng, Xin Chen, Weihua Zhai, Qiaoling Ma, Rongli Zhang, Jialin Wei, Aiming Pang, Yi He, Donglin Yang, Sizhou Feng, Mingzhe Han, Erlie Jiang   +15 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Case Report: Allogeneic hematopoietic stem cell transplantation in a patient with triple-allele expression at both HLA-B and HLA-C loci

Frontiers in Immunology
BackgroundHuman leukocyte antigen (HLA) matching is critical for donor selection in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Each HLA locus is normally biallelic; however, exceptionally rare cases with more than two alleles at a ...
Yoshiyuki Fujita, Kyoko Yoshihara, Kyoko Yoshihara, Daisuke Takahashi, Hidenori Tanaka, Yusuke Kino, Fuyuki Yamagata, Mami Samori, Saki Takahashi, Satoshi Yoshihara, Satoshi Yoshihara   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source