Results 71 to 80 of about 245,537 (258)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Outcomes of lung transplants utilizing donors from outside the continental United States

JHLT Open
Background: Efforts to expand the lung transplant donor pool have included re-evaluating geographic restrictions and accepting longer distances between donor and recipient centers. We evaluated the use of organs from donors outside the continental United
Reed T. Jenkins, MD, Emily L. Larson, MD, Alice L. Zhou, MD, Jessica M. Ruck, MD, PHD, David J. Farhat, MD, Helene Rached, DO, Al-Faraaz Kassam, MD, MBA, Christian A. Merlo, MD, Ramon A. Riojas, MD, Errol L. Bush, MD   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Addressing the translation gap in SCT donor selection

Frontiers in Immunology
Machine learning (ML) offers genuine promise for improving donor selection in hematopoietic stem cell transplantation (SCT), yet the gap between model development and clinical adoption remains wide.
David Higgins, Madlen Reschke, Madlen Reschke, Jonas Seiler, Jonathan P. Gross, Jonathan P. Gross, Jonathan P. Gross, Lena Oevermann, Lena Oevermann, Lena Oevermann   +9 more
doaj   +1 more source

Donor Selection

, 2017
AbstractAllogeneic haematopoietic stem cell transplant (HSCT) is the treatment of choice for a variety of malignant and non-malignant disorders. The aim of HSCT is to replace the patient’s haematopoiesis with that taken from a donor, and a prerequisite is the identification of a suitable donor.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Use of extended criteria donor cardiac allografts after multiple offers is associated with inferior post-transplant outcomes

JHLT Open
Purpose: Extended criteria donor (ECD) cardiac allografts have increased the donor pool for heart transplant (HT). The effect of donor sequence number (DSN), number of times a recipient’s donor organ has been offered prior to acceptance, on post-ECD HT ...
Cindy Song, MD, Amit Iyengar, MD, MSE, David Rekhtman, MD, Michaela Asher, MPhil, Max Shin, MD, Noah Weingarten, MD, Omar Toubat, MD, PhD, Mauer Biscotti, MD, Marisa Cevasco, MD, MPH   +8 more
doaj   +1 more source

Donor selection in the modern era

Annals of Cardiothoracic Surgery, 2018
The growing disparity between the supply of donor hearts for transplantation and the demand for such organs has led to liberalization of the criteria for donor heart acceptance over the past few decades. The upper age limit and size restrictions for donor heart acceptance continue to be revised and hearts are being routinely used from donors with left ...
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source