Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease
Annals of Neurology, EarlyView.Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay +5 more
wiley +1 more source
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
Angewandte Chemie, EarlyView.A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth +9 more
wiley +2 more sources
Levodopa induces thyroid function regulation in a patient with thyroid hormone resistance and Parkinson's disease: a case report. [PDF]
Front Endocrinol (Lausanne)Rozo-Paz G +4 more
europepmc +1 more source
Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease
Annals of Neurology, EarlyView.Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase ...
Verena Dzialas +4 more
wiley +1 more source
Regulation by Trace Amine-Associated Receptor 1 (TAAR1) of Dopaminergic-GABAergic Interaction in the Striatum: Effects of the Enhancer Drug (-)BPAP. [PDF]
Neurochem ResHarsing LG +3 more
europepmc +1 more source
Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship
Annals of Neurology, EarlyView.Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino +4 more
wiley +1 more source
Editorial: Exercise and neuroplasticity in Parkinson disease. [PDF]
Front NeurolHirsch MA, Dalgas U, van Wegen EEH.
europepmc +1 more source
Ketogenic diet, adenosine, and dopamine in addiction and psychiatry. [PDF]
Front NutrRuskin DN, Martinez LA, Masino SA.
europepmc +1 more source
Synthetische Ansätze für Molekül‐2D‐Übergangsmetalldichalkogenid‐Heterostrukturen
Angewandte Chemie, EarlyView.Die Integration von 2D‐Materialien in die Molekularchemie ermöglicht eine präzise Kontrolle über die Materialeigenschaften und verbessert deren Funktionalität. Molekül‐Übergangsmetalldichalkogenid‐Heterostrukturen (mTMDs, engl.: molecule‐transition metal dichalcogenides) sind aufgrund ihrer einzigartigen elektronischen, optischen und katalytischen ...
Sofiia Zuieva, Xin Chen
wiley +1 more source
Cabergoline as a preventive migraine treatment: A randomized clinical pilot trial. [PDF]
PLoS OneHjelholt AJ +5 more
europepmc +1 more source