Results 301 to 310 of about 589,499 (392)
Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long‐Term Functional Evaluation
Cell Proliferation, EarlyView.We optimised a protocol that combines developmental patterning with mechanical cut to produce pint‐sized midbrain organoids, with diameters less than 300 μm, suitable for long‐term evaluation, along with a comprehensive functional assay system consisting of calcium transient assay, neurite extension assay, and multielectrode array assay. ABSTRACT Human
Xinyue Wang +7 more
wiley +1 more source
Comparison of long-term use of prolonged-release ropinirole and immediate-release dopamine agonists in an observational study in patients with Parkinson's disease. [PDF]
Pharmacoepidemiol Drug Saf, 2020 Gungabissoon U +3 more
europepmc +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Due to the high frequency of laminitis reported for both conditions, the relationship between pituitary pars intermedia dysfunction (PPID) and insulin dysregulation (ID), and the potential role of dopamine in modifying insulin secretion, requires further investigation.
Nicolas C. Galinelli +7 more
wiley +1 more source
ICI-RS 2015 : is a better understanding of sleep the key in managing nocturia? [PDF]
, 2018 Cherian, Jerald +8 more
core +2 more sources
The FEBS Journal, EarlyView.Enhancing endocannabinoid signaling by targeting FAAH effectively mitigates cognitive deficits, reduces amyloid pathology, and modulates neuroinflammatory responses in a preclinical model of Alzheimer's disease. This effect is potentially mediated by attenuating the Aβ‐induced overexpression of the Bace1 gene through CB1‐dependent hypermethylation of ...
Sergio Oddi +12 more
wiley +1 more source
A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains
The FEBS Journal, EarlyView.Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley +1 more source
“Don't Work for Soyciety:” Involuntary Celibacy and Unemployment
Gender, Work &Organization, EarlyView.ABSTRACT Surveys of involuntary celibates (“incels”) suggest that they tend to be not in education, employment or training (NEET) at disproportionately high rates. However, it remains unclear whether and how being NEET is connected to incels' ideology and life circumstances.
AnnaRose Beckett‐Herbert, Eran Shor
wiley +1 more source
Journal of Advanced Nursing, EarlyView.ABSTRACT Aims To explore how nurse practitioners experienced and understood development of their capability providing medication for opioid use disorder and safe supply in North American primary care settings. Design A phenomenographic approach was applied to the study design, recruitment, and analysis. Methods Semi‐structured interviews were conducted
Martha M. Whitfield +4 more
wiley +1 more source
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Background Gut microbiota plays a crucial role in the pathogenesis and treatment of functional constipation (FC). The aim of this study was to explore the therapeutic effects of Bifidobacterium Lactobacillus triple viable on slow transit constipation (STC).
Mei Luo +4 more
wiley +1 more source