Results 121 to 130 of about 128,837 (259)

Distinct roles of dopamine receptors in HIV latency reversal in a myeloid cell model. [PDF]

Front Immunol
Basova LV, Riley T, Delorme-Walker V, de Siqueira-Lima D, Milner R, Ellis RJ, Fox H, Marcondes MCG.   +7 more
europepmc   +1 more source

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Abnormally high expression of D1-like dopamine receptors on lupus CD4⁺ T cells promotes Tfh cell differentiation. [PDF]

Lupus Sci Med, 2023
Wu F, Xiang Z, He Z, Yi P, Yang M, Wu H, Hu M.   +6 more
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Analysis of clinical trials on drugs targeting dopamine receptors: a scoping review. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Rajan T, Seifert R.
europepmc   +1 more source

Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others. [PDF]

Nat Commun, 2023
Mikus N, Eisenegger C, Mathys C, Clark L, Müller U, Robbins TW, Lamm C, Naef M.   +7 more
europepmc   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Involvement of D1- and D2-like dopamine receptors in the hippocampal CA1 region in mediating the restraint stress-induced analgesia in the rats. [PDF]

IBRO Neurosci Rep
Shirmohammadi D, Golmohammadi H, Abtin S, Haghparast A.   +3 more
europepmc   +1 more source

Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective. [PDF]

Front Synaptic Neurosci, 2022
Gerfen CR.
europepmc   +1 more source

Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors. [PDF]

Drug Alcohol Depend, 2023
Guttman Z, Mandelkern M, Ghahremani DG, Kohno M, Dean AC, London ED.   +5 more
europepmc   +1 more source