Results 301 to 310 of about 112,428 (350)

The dopamine transporter: A crucial component regulating dopamine transmission

Movement Disorders, 1997
AbstractThe dopamine system is implicated in the control of locomotion, cognition, and endocrine function, The relative contribution of the various dopamine‐related components is not well established mainly because drugs that target the dopaminergic system often lack selectivity.
Mohamed Jaber, Sara R Jones, Bruno Giros   +2 more
exaly   +3 more sources

Neuroleptics and Dopamine Transporters

Neurochemical Research, 1998
The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostriatum and substantia nigra, after ...
T A, Reader, A R, Ase, N, Huang, C, Hébert, N M, van Gelder   +4 more
openaire   +2 more sources

Decreases in Dopamine Receptors but not in Dopamine Transporters in Alcoholics

Alcoholism: Clinical and Experimental Research, 1996
It has been hypothesized that ethanol's actions on the dopamine (DA) system may participate in addiction. The purpose of this study was to evaluate the DA system in the brain of alcoholics. We evaluated 10 alcoholics and 17 nonalcoholics using positron emission tomography and [11C]raclopride to measure DA D2 receptors.
N D, Volkow, G J, Wang, J S, Fowler, J, Logan, R, Hitzemann, Y S, Ding, N, Pappas, C, Shea, K, Piscani   +8 more
openaire   +2 more sources

Role of dopamine transporter (DAT) in dopamine transport across the nasal mucosa

Life Sciences, 2006
Dopamine is a catecholamine neurotransmitter necessary for motor functions. Its deficiency has been observed in several neurological disorders, but replacement of endogenous dopamine via oral or parenteral delivery is limited by poor absorption, rapid metabolism and the inability of dopamine to cross the blood-brain barrier.
Nagendra V, Chemuturi, Jon E, Haraldsson, Thomas, Prisinzano, Maureen, Donovan   +3 more
openaire   +2 more sources

Dopamine receptor and dopamine transporter in obesity: A meta‐analysis

Synapse, 2022
Abstract The brain plays a major role in controlling the desire to eat. This meta‐analysis aimed to assess the association between dopamine receptor (DR) availability and dopamine transporter (DAT) availability, measured using positron emission tomography, and obesity.
Kyoungjune Pak, Ju Won Seok, Myung Jun Lee, Keunyoung Kim, In Joo Kim   +4 more
openaire   +2 more sources

Molecular characterization of the dopamine transporter

Trends in Pharmacological Sciences, 1993
Neurotransmission, which represents chemical signalling between neurons, usually takes place at highly differentiated anatomical structures called synapses. To fulfill both the time and space confinements required for optimal neurotransmission, highly specialized proteins, known as transporters or uptake sites, occur and operate at the presynaptic ...
B, Giros, M G, Caron
openaire   +2 more sources

Dopamine transporters and neuronal injury

Trends in Pharmacological Sciences, 1999
The plasma membrane dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) are essential for normal dopamine neurotransmission. DAT terminates the actions of dopamine by rapidly removing dopamine from the synapse, whereas VMAT2 loads cytoplasmic dopamine into vesicles for storage and subsequent release.
G W, Miller, R R, Gainetdinov, A I, Levey, M G, Caron   +3 more
openaire   +2 more sources

Limited power of dopamine transporter mRNA mapping for predicting dopamine transporter availability

Synapse, 2022
AbstractDopamine transporters (DAT) are transmembrane proteins that translocate dopamine from the extracellular space into presynaptic neurons. We aimed to investigate the predictive power of DAT mRNA for DAT protein expression, measured using positron emission tomography (PET). We performed 18F‐FP‐CIT PET scans in 35 healthy individuals.
Kyoungjune Pak, Seongho Seo, Myung Jun Lee, Hyung‐Jun Im, Keunyoung Kim, In Joo Kim   +5 more
openaire   +2 more sources

The dopamine transporter proteome

Journal of Neurochemistry, 2006
AbstractDopamine (DA) uptake through the neuronal plasma membrane DA transporter (DAT) is essential for the maintenance of normal DA homeostasis in the brain. The DAT‐mediated re‐uptake system limits not only the intensity but also the duration of DA actions at presynaptic and postsynaptic receptors.
openaire   +2 more sources

Thermal Stability of Dopamine Transporters

The Journal of Membrane Biology, 2015
The thermal stabilities of the rat and mouse dopamine transporter (DAT) proteins were studied within the temperature range of 0-37°C. The inactivation of the protein was followed by monitoring changes in radioligand-specific binding. We found that the process followed a rate equation with first-order kinetics and was characterized by having a single ...
Siim, Kukk, Vladimir, Stepanov, Jaak, Järv   +2 more
openaire   +2 more sources