Results 311 to 320 of about 112,428 (350)

Interaction of Isoflurane with the Dopamine Transporter

Anesthesiology, 2003
Background Isoflurane administration is known to increase extracellular dopamine (DA) concentration. Because the dopamine transporter (DAT) is a key regulator of DA, it is likely affected by isoflurane. This study investigates the hypothesis that isoflurane inhibits DA reuptake by causing DAT to be trafficked into the cell.
John, Votaw, Michael, Byas-Smith, Jian, Hua, Ronald, Voll, Laurent, Martarello, Allan I, Levey, F DuBois, Bowman, Mark, Goodman   +7 more
openaire   +2 more sources

Regulation of the Dopamine Transporter by Phosphorylation

2006
The dopamine transporter (DAT) is a neuronal phosphoprotein and target for psychoactive drugs that plays a critical role in terminating dopaminergic transmission by reuptake of dopamine from the synaptic space. Control of DAT activity and plasma membrane expression are therefore central to drug actions and the spatial and temporal regulation of ...
J D, Foster, M A, Cervinski, B K, Gorentla, R A, Vaughan   +3 more
openaire   +2 more sources

A putative model of the dopamine transporter

Molecular Brain Research, 1994
A three-dimensional model of the human dopamine transporter was constructed by molecular modeling techniques from its amino acid sequence, based on sequence analysis of this and 9 other transporter proteins. The model has 12 membrane spanning alpha-helices arranged in two 7-helical bundles, loops between helices and amino- and carboxy termini.
O, Edvardsen, S G, Dahl
openaire   +2 more sources

Dopamine Transporter Network and Pathways

2004
Publisher Summary This chapter explains the dopamine transporter network and pathways. The family of Na + and Cl - dependent transporters that includes the dopamine (DA), and norepinephrine (NE) transporters (DAT and NET, respectively), functions to clear released neurotransmitters from the synaptic cleft.
Rajani, Maiya, R Dayne, Mayfield
openaire   +2 more sources

Dopamine transporter mediated release of dopamine: Role of chloride

Journal of Neuroscience Research, 1994
AbstractUsing a rapid (0.5 ml/min) flow rate superfusion system, the dopamine (DA) transporter mediated release of DA is further explored, and compared to the depolarization evoked release of DA in rat striatal synaptosomes preloaded with radioactive DA (3H‐DA).
M, Sitges, A, Reyes, L M, Chiu
openaire   +2 more sources

Molecular imaging of dopamine transporters

Ageing Research Reviews, 2016
The dopamine transporter (DAT) is responsible for clearance of dopamine from the synaptic cleft after its release. Imaging DAT availability provides a measure of dopamine terminal function and a method for detecting the striatal dopamine terminal dysfunction present in idiopathic Parkinson's disease (PD) and atypical neurodegenerative parkinsonian ...
openaire   +2 more sources

Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users

Annals of Neurology, 1996
AbstractDepletion of striatal dopamine (DA) has been hypothesized to explain some of the neurological and psychiatric complications of chronic use of cocaine, including increased risk for neuroleptic‐precipitated movement disorders. We measured levels of DA, as well as two DA nerve terminal indices, namely, the DA transporter (DAT) and the vesicular ...
J M, Wilson, A I, Levey, C, Bergeron, K, Kalasinsky, L, Ang, F, Peretti, V I, Adams, J, Smialek, W R, Anderson, K, Shannak, J, Deck, H B, Niznik, S J, Kish   +12 more
openaire   +2 more sources

Astroglial dopamine transport is mediated by norepinephrine transporter

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002
The aim of this study was to clarify the characteristics of the dopamine (DA) transport mechanism in cultured rat cortical astrocytes. Reverse transcription-polymerase chain reaction (RT-PCR) with DA transporter (DAT)-, norepinephrine (NE) transporter (NET)- and organic cation transporter 3 (OCT3)-specific primers demonstrated that rat cortical ...
Hiroshi, Takeda, Masato, Inazu, Teruhiko, Matsumiya   +2 more
openaire   +2 more sources

Dopamine reuptake and inhibitory mechanisms in human dopamine transporter

Nature
The dopamine transporter has a crucial role in regulation of dopaminergic neurotransmission by uptake of dopamine into neurons and contributes to the abuse potential of psychomotor stimulants1-3. Despite decades of study, the structure, substrate binding, conformational transitions and drug-binding poses of human dopamine transporter remain unknown ...
Yue Li, Xianping Wang, Yufei Meng, Tuo Hu, Jun Zhao, Renjie Li, Qinru Bai, Pu Yuan, Jun Han, Kun Hao, Yiqing Wei, Yunlong Qiu, Na Li, Yan Zhao   +13 more
openaire   +2 more sources

Dopamine transporter imaging

Movement Disorders, 2003
Andrew J, Lees, Donald G, Grosset
openaire   +2 more sources