Results 291 to 300 of about 402,660 (356)
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A dopaminergic mechanism in mania
American Journal of Psychiatry, 1976The authors present a case study that explores the relationship of dopamine function and manic illness through the use of two drugs with relatively specific effects in stimulating and blocking dopamine receptors--piribedil (ET--495) and pimozide, respectively.
R H, Gerner, R M, Post, W E, Bunney
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Dopaminergic properties of nomifensine
Pharmacology Biochemistry and Behavior, 1982Nomifensine and a proposed dihydroxy metabolite produced stimulation of motor behavior in mice with nomifensine being more potent. Weak cage-climbing behavior (stereotypy) was also produced. The stimulatory effects were greater in mice in which dopamine receptor sensitivity was increased by long-term haloperidol.
G, Gianutsos +3 more
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Is there a ?dopaminergic glial cell??
Neurochemical Research, 1984Intracellular cAMP increased 9-fold in cerebral hemisphere primary cultures after incubation with dopamine (10(-4) M). The effect was dose- and time-dependent (10(-6) M-10(-4) M; 2-10 minutes). It was mimicked, to some extent, by the partial agonist apomorphine (10(-5) M-10(-4) M) and antagonized by fluphenazine (10(-5) M-10(-4) M).
E, Hansson, L, Rönnbäck, A, Sellström
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Nature, 1978
THE clinical treatment of parkinsonism with the dopamine (DA) precursor L-dopa has certain drawbacks1 and there are relatively few drugs which directly stimulate DA receptors (although there are many which block them, such as the neuroleptics). There is thus great industrial, academic and clinical interest in the development of new DA-receptor ...
A S, Horn +7 more
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THE clinical treatment of parkinsonism with the dopamine (DA) precursor L-dopa has certain drawbacks1 and there are relatively few drugs which directly stimulate DA receptors (although there are many which block them, such as the neuroleptics). There is thus great industrial, academic and clinical interest in the development of new DA-receptor ...
A S, Horn +7 more
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Dopaminergic influences on swallowing☆
Neuropharmacology, 1977Abstract Oropharyngeal twitch activity (OTA) exhibited spontaneously in the rat under urethane anaesthesia was compared with swallowing elicited reflexly by electrical stimulation of the superior laryngeal nerve (SLN) or intraoral injection of water. Deglutition was monitored by recording EMGs from muscles of the floor of the mouth, neck and pharynx,
D, Bieger, S A, Giles, C H, Hockman
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The dopaminergic system in hypertension
Clinical Science, 2007Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport, vascular smooth muscle contractility and production of reactive oxygen species and by interacting with the renin–angiotensin and sympathetic nervous systems.
Chunyu, Zeng +4 more
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Flavonoids as dopaminergic neuromodulators
Molecular Nutrition & Food Research, 2016ScopeThe present study aimed to characterize and evaluate flavonoids effects on organic cation uptake in neuronal cells.Methods and resultsUptake experiments were conducted using radiolabeled methyl‐4‐phenylpyridinuim ([3H]‐MPP+), in human neuronal dopaminergic cells, SH‐SY5Y.
Meireles, M. +8 more
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Apomorphine in Dopaminergic Therapy
Molecular Pharmaceutics, 2006Apomorphine is a potent molecule for the treatment of Parkinson's disease (PD). It can be obtained in both the R and S forms, and it is the former that is the therapeutically active form. Due to its structural similarity with 3,4-dihydroxyphenethylamine, dopamine, apomorphine can function as an agonist in the treatment of PD as it can stimulate both ...
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Ethanol and dopaminergic systems
Pharmacology Biochemistry and Behavior, 1983Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the
Lucchi L +5 more
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The dopaminergic amacrine cell
Journal of Comparative Neurology, 1990AbstractThe detailed morphology of the dopaminergic amacrine cell type has been characterized in the macaque monkey retina by intracellular injection of horseradish peroxidase (HRP). This cell type was recognized by its large soma in an in vitro, wholemount preparation of the retina stained with the fluorescent dye, acridine orange.
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