Results 301 to 310 of about 402,660 (356)
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Caffeine and the dopaminergic system
Behavioural Pharmacology, 2005Caffeine is the most widely consumed psychostimulant substance, being self-administered throughout a wide range of conditions and present in numerous dietary products. Due to its widespread use and low abuse potential, caffeine is considered an atypical drug of abuse.
CAULI O, MORELLI, MICAELA
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Dopaminergic Disturbances in Tourette Syndrome: An Integrative Account.
Biological Psychiatry, 2018Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters ...
T. Maia, Vasco A Conceição
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[Continuous dopaminergic stimulation, pulsatile dopaminergic stimulation].
Revue neurologique, 2003Levodopa is the gold standard treatment for Parkinson's disease. The therapeutic effect may however be compromised by the inevitable risk of motor complications, with fluctuating motor control and dyskinesia, particularly in the younger patient. The Multiple pathophysiological mechanisms are undoubtedly involved but pulsed dopaminergic stimulation ...
A., Destée, R., Bordet
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Dopaminergic defect in hypertension
Pediatric Nephrology, 1993Reverse genetics and the candidate gene approach have been utilized to identify the genetic defect(s) in hypertension. We have proposed the dopamine receptor gene as one candidate in the pathogenesis of hypertension. Because some forms of hypertension are sodium dependent or aggravated by sodium loading and because dopamine is important in aiding the ...
P A, Jose, G M, Eisner, R A, Felder
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Peripheral dopaminergic nerves
Pharmacology & Therapeutics, 1989The concept that dopamine (DA) might have a parallel role as a neurotransmitter in the peripheral nervous system has an even shorter history, but recent research, especially since the advent of immunohistochemical techniques, has provided a wide spectrum of supportive evidence.
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Dopaminergic activity of quipazine
Pharmacology Biochemistry and Behavior, 1982Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Administration of 1.0 mg/kg quipazine, a putative serotonin agonist, produced apomorphine-appropriate responding with a maximal effect occurring at 45 min post-injection.
M D, Schechter, J T, Concannon
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The organization of dopaminergic and non-dopaminergic mesencephalo-cortical neurons in the rat
Brain Research, 1982The dopamine containing mesencephalo-cortical pathway was studied in the rat by means of a combined retrograde fluorescent tracing and catecholamine histofluorescence technique. After large injections of the fluorescent retrograde tracer, Evans blue, into the frontal cortex, many neural somata of the ventral midbrain tegmentum were retrogradely labeled;
Albanese, Alberto, Bentivoglio, M.
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The role of dopaminergic imaging in patients with symptoms of dopaminergic system neurodegeneration
Brain, 2011Diagnosis of neurological and psychiatric conditions associated with disturbances of dopaminergic functioning can be challenging, especially in the early stages, and may be assisted with biomarkers such as dopamine system imaging. Distinguishing between Alzheimer's disease and dementia with Lewy bodies is a major diagnostic challenge.
Jeffrey L, Cummings +5 more
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Journal of Neural Transmission, 1980
Bromocriptine reduces the spontaneous firing rate of neurons in the pars compacta of the substantia nigra but does not change the electrical activity of the neurons located in the pars reticulata. On the other hand, bromocriptine induces contralateral circling behaviour in rats with unilateral 6-hydroxydopamine nigral lesion.
SCARNATI, Eugenio +4 more
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Bromocriptine reduces the spontaneous firing rate of neurons in the pars compacta of the substantia nigra but does not change the electrical activity of the neurons located in the pars reticulata. On the other hand, bromocriptine induces contralateral circling behaviour in rats with unilateral 6-hydroxydopamine nigral lesion.
SCARNATI, Eugenio +4 more
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A Diet for Dopaminergic Neurons?
2009Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive ...
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