Results 321 to 330 of about 835,318 (379)
Dopaminergic neurons in the human retina [PDF]
Journal of Comparative Neurology, 1982 AbstractThe utilization of dopamine in the adult human retina was examined by using high‐affinity uptake, localization, synthesis, and release as neurotransmitter‐specific physiological probes. Autoradiographic and histochemical studies have shown that dopamine‐accumulating and dopamine‐containing cells of the human retina belong to a population of ...
Mary E. Rayborn +4 more
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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
Science, 1993A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the ...
L.-F. H. Lin +4 more
semanticscholar +1 more source
The International Journal of Biochemistry & Cell Biology, 2005
Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Julie K. Andersen, Shankar J. Chinta
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Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Julie K. Andersen, Shankar J. Chinta
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Dopaminergic neurons for Parkinson's therapy [PDF]
Nature Biotechnology, 2012 A differentiation protocol guided by developmental principles produces more-authentic dopaminergic neurons for transplantation in patients.
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Dopaminergic neurons intrinsic to the striatum
Journal of Neurochemistry, 2007AbstractThe striatum – the largest integrative component of the basal ganglia – harbors a population of neurons that express the enzyme tyrosine hydroxylase (TH), a faithful marker of dopaminergic neurons. The dopaminergic nature of these neurons is further supported by the fact that they express the dopamine (DA) transporter (DAT) and the nuclear ...
André Parent, Philippe Huot
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ACS Chemical Neuroscience, 2017
In 1967, L-dopa was introduced as part of the pharmacological therapy of Parkinson's disease (PD) and, in spite of extensive research, no additional effective drugs have been discovered to treat PD. This brings forward the question: why have no new drugs
Andrea Herrera +3 more
semanticscholar +1 more source
In 1967, L-dopa was introduced as part of the pharmacological therapy of Parkinson's disease (PD) and, in spite of extensive research, no additional effective drugs have been discovered to treat PD. This brings forward the question: why have no new drugs
Andrea Herrera +3 more
semanticscholar +1 more source
Toxicity of semaphorin3A for dopaminergic neurons
Neuroscience Letters, 2005Semaphorin3A (Sema3A) is known to cause neuronal apoptosis and serves as a chemorepellent factor for axonal growth. In our previous report, we found that Sema3A was up-regulated in the 6-OHDA-injected striatum of rats, suggesting that Sema3A was likely involved in dopaminergic (DA) depletion.
Isao Date +11 more
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Current Stem Cell Research & Therapy, 2017
Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain ...
Katari Venkatesh, D. Sen
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Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain ...
Katari Venkatesh, D. Sen
semanticscholar +1 more source
A Diet for Dopaminergic Neurons?
2009Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive ...
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