Results 91 to 100 of about 377,374 (317)

Intrathecal Immunoglobulin A Synthesis in Multiple Sclerosis: From Biological Aspects to Clinical Relevance

open access: yesBiomolecules
Intrathecal immunoglobulin A (IgA) synthesis in multiple sclerosis (MS) has long earned little attention, despite a potential significance in disease pathogenesis and prognosis.
Dariia Kliushnikova   +4 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung   +19 more
wiley   +1 more source

Tissue Doppler imaging following paediatric cardiac surgery : early patterns of change and relationship to outcome

open access: yes, 2009
In this study, tissue Doppler imaging (TDI) was used to assess changes in ventricular function following repair of congenital heart defects. The relationship between TDI indices, myocardial injury and clinical outcome was explored.
Peng, E.   +17 more
core   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu   +10 more
wiley   +1 more source

Processing of CW Doppler images to extract velocity profile [PDF]

open access: yes, 2012
The present work aims to find a good way to automatically trace the velocity profile in vessels shown in continuous wave Doppler spectrograms, replacing the more traditional manual tracing, easy to perform but rich in drawbacks.
Dainese, Clara
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

Solving the inverse magnetostatic problem using fictitious magnetic charges

open access: yesAIP Advances, 2018
We present a method for solving the inverse magnetostatic problem using fictitious magnetic charges. The method utilizes the fact that a given magnetic stray field is generated by only one unique charge distribution.
Gregor Wautischer   +5 more
doaj   +1 more source

Use of ultrasonography for fetal circulation assessment in canine pregnancy: A review [PDF]

open access: yesRevista Brasileira de Saúde e Produção Animal
This literature review discusses advances in gestational ultrasound in bitches, focusing on the use of Doppler technology for maternal-fetal hemodynamic assessment.
Maíra Planzo Fernandes   +4 more
doaj   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

open access: yesAdvanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong   +6 more
wiley   +1 more source

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