Results 261 to 270 of about 596,703 (340)

Three‐Year Diagnostic Delay in Shrinking Lung Syndrome: Rituximab‐Theophylline Combination as Rescue Therapy

open access: yesRespirology Case Reports, Volume 14, Issue 1, January 2026.
This report presents a case of systemic lupus erythematosus with multiple hospitalizations over 3 years due to unexplained respiratory symptoms (dyspnea, reduced lung volume, elevated diaphragm, coughing, and chest pain), ultimately diagnosed with shrinking lung syndrome (a rare complication of lupus without established treatment) and successfully ...
Somayeh Motamed   +5 more
wiley   +1 more source

Low and High Pressor Doses of Ang II Lead to Two Distinct Phenotypes of Hypertensive Heart Disease in Mice

open access: yesAPMIS, Volume 134, Issue 1, January 2026.
ABSTRACT Hypertension is a major contributor to cardiovascular diseases, being the most common comorbidity and the biggest risk factor in heart failure with preserved ejection fraction. Angiotensin II (Ang II) is a known hypertension and heart failure inducer in mice, but its role in the causality in phenotype development remains unclear.
Diana Törmä   +5 more
wiley   +1 more source

Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System

open access: yesCell Proliferation, Volume 59, Issue 1, January 2026.
In this study, Bai et al. established a co‐culture system between neural organoids (NOs) and engineered heart tissues (EHTs) and demonstrated that NOs could secrete versican, which was absorbed by EHTs to ameliorate glucolipotoxicity. ABSTRACT Metabolic disorders could cause dysregulated glucose and lipid at the systemic level, but how inter‐tissue ...
Baochen Bai   +22 more
wiley   +1 more source

Pediatric Lung Waitlist Score (PLWS): A Score to Predict Waitlist Time for Pediatric Lung Transplant Candidates

open access: yesClinical Transplantation, Volume 40, Issue 1, January 2026.
ABSTRACT Background: In pediatric lung transplantation, the ability to estimate the projected waiting time could be particularly helpful for candidates and physicians. A score to predict waiting time has yet to be developed in this field. The purpose of this study was to create a score that predicts waitlist time for pediatric patients who are listed ...
Jose Ramirez   +2 more
wiley   +1 more source

Clinical outcomes of transcatheter edge‐to‐edge repair in patients with functional mitral regurgitation and pulmonary hypertension

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
This study reveals that patients with PH have worse clinical outcomes, in terms of hospitalization for heart failure (HF) and the composite endpoint of HF hospitalization and death at 1‐year follow‐up, compared with patients without PH. In particular, the hemodynamic subgroup of combined post‐ and pre‐capillary PH is associated with worse clinical ...
Alessandro Mandurino‐Mirizzi   +11 more
wiley   +1 more source

A matter arising: When should inflammatory and autoimmune rheumatic diseases be considered ‘early’?

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Timely recognition of inflammatory and autoimmune rheumatic diseases (IARDs) is important to optimize the early diagnosis with tailored interventions and possible prevention of irreversible organ damage. This narrative review provides an update by summarizing the advances in identifying the early stages of rheumatoid arthritis, systemic sclerosis and ...
Elvis Hysa   +7 more
wiley   +1 more source

Hemodynamic and microcirculatory early adaptations following transcatheter aortic valve implantation (TAVI): A physiological pilot study

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
This pilot physiological study, involving 20 patients with severe aortic stenosis, shows that transcatheter aortic valve implantation (TAVI) induces rapid changes in both macrocirculatory parameters, reflecting the release of chronic obstruction. We observed improved tissue perfusion by postoperative Day 1, independent of macrocirculatory parameters ...
Stanislas Abrard   +12 more
wiley   +1 more source

Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction

open access: yesThe FEBS Journal, Volume 293, Issue 2, Page 418-442, January 2026.
We analysed collagen XV expression in myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness. In mice, damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel ...
Sanna‐Maria Karppinen   +15 more
wiley   +1 more source

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