Results 131 to 140 of about 16,506,777 (367)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Atividade antioxidante, composição química e conservação do maracujá-amarelo embalado com filme PVC [PDF]

, 2013
Maria Cristina Copello Rotili, Jéssica Ariane Vorpagel, Gilberto Costa Braga, Odair José Kuhn, Ariane Busch Salibe   +4 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Spacecraft-spacecraft very long baseline interferometry. Part 1: Error modeling and observable accuracy [PDF]

In Part 1 of this two-part article, an error budget is presented for Earth-based delta differential one-way range (delta DOR) measurements between two spacecraft.
Border, J. S., Edwards, C. D., Jr.
core   +1 more source

Assessment of the components of fluid balance in patients with septic shock: a prospective observational study

Brazilian Journal of Anesthesiology
Background: The optimal amount for initial fluid resuscitation is still controversial in sepsis and the contribution of non-resuscitation fluids in fluid balance is unclear. We aimed to investigate the main components of fluid intake and fluid balance in
Maria Aparecida de Souza, Fernando José da Silva Ramos, Bianca Silva Svicero, Nathaly Fonseca Nunes, Rodrigo Camillo Cunha, Flavia Ribeiro Machado, Flavio Geraldo Rezende de Freitas   +6 more
doaj   +1 more source

Prevenção e monitorização do delirium no idoso: uma intervenção educativa [PDF]

, 2016
Tássia Nery Faustino, Larissa Chaves Pedreira, Yasmin Seixas de Freitas, Rosana Maria de Oliveira Silva, Juliana Bezerra do Amaral   +4 more
openalex   +1 more source

Do Low Interest Rates Sow the Seeds of Financial Crises?

, 2021
Simona E. Cociuba, Malik Shukayev, Alexander Ueberfeldt   +2 more
openalex   +2 more sources

Dor aguda e crônica: revisão narrativa da literatura

, 2012
Os objetivos do estudo foram identificar as repercussoes orgânicas, emocionais e psiquicas prevalentes em pacientes com dor aguda e dor cronica e pontuar os principais instrumentos de avaliacao para essas dores.
A. M. Sallum, D. M. Garcia, Mariana Bucci Sanches   +2 more
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source