Results 141 to 150 of about 3,618,545 (328)

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

open access: yesFEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti   +8 more
wiley   +1 more source

A questão da espiritualidade na realidade hospitalar: o psicólogo e a dimensão espiritual do paciente

open access: yesEstudos de Psicologia (Campinas)
Visando minimizar o sofrimento psicológico de pacientes Fora de Possibilidade de Cura e promover Qualidade de Vida na Dor Simbólica da Morte, representada pela Dor Psíquica e Dor Espiritual, desenvolveu - se um método integrando - se as técnicas de ...
Ana Catarina de Araújo Elias   +1 more
doaj   +1 more source

The net effect of unemployment benefits, sanctions and training on regular employment [PDF]

open access: yes
This paper measures the impact of labor market policies (LMPs) on regular employment. Contrary to previous empirical studies, we conduct an econometric analysis based on sound theoretical foundations.
Bruno Van der Linden, Eric Dor
core  

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

open access: yesFEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro   +8 more
wiley   +1 more source

Dor - aspectos fisiopatológicos

open access: yesActa Fisiátrica, 1995
Neste artigo foram revistos os diversos níveis de integração do fenômeno nociceptivo, bem como o interrelacionamento da nocicepção com os demais elementos sensoriais, mnésticos e motivacionais. Enfatizou-se neste artigo o caráter multidimensional do fenômeno doloroso.
openaire   +3 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

open access: yesAging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth   +7 more
wiley   +1 more source

Sôbre Naididae do Brasil

open access: gold, 1943
Ernst Marcus
openalex   +1 more source

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