Genetic Engineering Methods in Primary T Cells
Advanced Therapeutics, EarlyView.Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley +1 more source
Evolution of Ocular Organ‐On‐Chip Systems for Disease Modelling and Drug Testing: Where are We Now?
Advanced Therapeutics, EarlyView.The rise in ophthalmic diseases due to aging, screen use, and environmental factors has driven demand for better ocular models. Traditional systems fall short, encouraging the development of organ‐on‐chip devices. These microfluidic platforms replicate eye tissue architecture, enable drug screening, and simulate ocular diseases.
Sara Trujillo
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Growth factor requirement for survival in cell-cycle dormancy of primitive murine lymphohematopoietic progenitors [PDF]
, 1993 Naoyuki Katayama, SC Clark, Makio Ogawa
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Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Peach Seedling Emergence and Growth in Response to Isothermal and Cycled Stratification Treatments Reveal Two Dormancy Components [PDF]
, 1998 Schuyler D. Seeley +2 more
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The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots
Advanced Science, EarlyView.DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya +6 more
wiley +1 more source
Slow-cycling (dormant) cancer cells in therapy resistance, cancer relapse and metastasis
, 2021 Sukanya Basu +4 more
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Inflammation is a key contributor to ovarian cancer cell seeding. [PDF]
, 2018 The incidence of ovarian cancer dramatically increases in early menopause but the factors contributing to cancer onset are unclear. Most ovarian cancers originate in the fallopian tube with subsequent implantation of malignant cells into the ovary ...
Jia, Dongyu +3 more
core +1 more source
EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells
Advanced Science, EarlyView.ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li +15 more
wiley +1 more source