Representation of Dormant and Active Microbial Dynamics for Ecosystem Modeling [PDF]
, 2013 Dormancy is an essential strategy for microorganisms to cope with environmental stress. However, global ecosystem models typically ignore microbial dormancy, resulting in major model uncertainties.
Gu, Lianhong +3 more
core +3 more sources
Model of tumor dormancy/recurrence after short-term chemotherapy.
PLoS ONE, 2014 Although many tumors regress in response to neoadjuvant chemotherapy, residual tumor cells are detected in most cancer patients post-treatment. These residual tumor cells are thought to remain dormant for years before resuming growth, resulting in tumor ...
Shenduo Li +6 more
doaj +1 more source
The Dormancy Dilemma: Quiescence versus Balanced Proliferation [PDF]
, 2013 Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of morbidity and mortality from most solid tumors. Even more daunting is that many of these metastatic deposits silently lie undetected, recurring years to decades ...
Griffith, Linda G. +3 more
core +2 more sources
Microbes as engines of ecosystem function : When does community structure enhance predictions of ecosystem processes? [PDF]
, 2016 FUNDING This work was supported by NSF grant DEB-1221215 to DN, as well as grants supporting the generation of our datasets as acknowledged in their original publications and in Supplementary Table S1. ACKNOWLEDGMENT We thank the USGS Powell Center ‘Next
Alessandra eLagomarsino +52 more
core +5 more sources
Tumor Dormancy and Slow-Cycling Cancer Cells
, 2019 Cancer cell heterogeneity is a universal feature of human tumors and represents a significant barrier to the efficacy and duration of anticancer therapies, especially targeted therapeutics. Among the heterogeneous cancer cell populations is a subpopulation of relatively quiescent cancer cells, which are in the G0/G1 cell-cycle phase and refractory to ...
Dean G. Tang +3 more
openaire +4 more sources
Coupling of the radiosensitivity of melanocyte stem cells to their dormancy during the hair cycle [PDF]
Pigment Cell & Melanoma Research, 2014 SummaryCurrent studies have revealed that stem cells are more radiosensitive than mature cells. As somatic stem cells are mostly kept in a quiescent state, this conflicts with Bergonié and Tribondeau's law that actively mitotic cells are the most radiosensitive. In this study, we focused on hair graying to understand the stress‐resistance of melanocyte
Yasuaki Mohri +4 more
openaire +4 more sources
Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche. [PDF]
, 2016 While implicated in therapeutic resistance, malignant progenitor cell cycle kinetics have been difficult to quantify in real-time. We developed an efficient lentiviral bicistronic fluorescent, ubiquitination-based cell cycle indicator reporter (Fucci2BL)
Delos Santos, Nathaniel P +10 more
core +1 more source
High-severity wildfire leads to multi-decadal impacts on soil biogeochemistry in mixed-conifer forests. [PDF]
, 2020 During the past century, systematic wildfire suppression has decreased fire frequency and increased fire severity in the western United States of America.
Bell C. W. +7 more
core +2 more sources
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
core +2 more sources
Stem Cell Reports, 2018 Summary: The existence of slow-cycling luminal cells in the prostate has been suggested, but their identity and functional properties remain unknown.
Dingxiao Zhang +6 more
doaj +1 more source