Callose is an important polysaccharide composed of beta-1,3-glucans and is widely implicated in plant development and defense responses. Callose synthesis is mainly catalyzed by a family of callose synthases, also known as glucan synthase-like (GSL ...
Man Zhang+6 more
doaj +1 more source
A Cellular Automaton Model for Tumor Dormancy: Emergence of a Proliferative Switch [PDF]
Malignant cancers that lead to fatal outcomes for patients may remain dormant for very long periods of time. Although individual mechanisms such as cellular dormancy, angiogenic dormancy and immunosurveillance have been proposed, a comprehensive understanding of cancer dormancy and the "switch" from a dormant to a proliferative state still needs to be ...
arxiv +1 more source
To germinate or not to germinate : a question of dormancy relief not germination stimulation [PDF]
A common understanding of the control of germination through dormancy is essential for effective communication between seed scientists whether they are ecologists, physiologists or molecular biologists. Vleeshouwers et al.
Batlla+4 more
core +1 more source
Models of Microbial Dormancy in Biofilms and Planktonic Cultures [PDF]
We present models of dormancy in a planktonic culture and in biofilm, and examine the relative advantage of short dormancy versus long dormancy times in each case. Simulations and analyses indicate that in planktonic batch cultures and in chemostats, live biomass is maximized by the fastest possible exit from dormancy.
arxiv +1 more source
Deciphering a Sleeping Pathogen: Uncovering Novel Transcriptional Regulators of Hypoxia-Induced Dormancy in Mycobacterium Tuberculosis [PDF]
Along the pathogenesis of Mycobacterium Tuberculosis (MTB), hypoxia-induced dormancy is a process involving the oxygen-depleted environment encountered inside the lung granuloma, where bacilli enter a viable, non-replicating state termed as latency. Affecting nearly two billion people, latent TB can linger in the host for indefinite periods of time ...
arxiv
Model of tumor dormancy/recurrence after short-term chemotherapy.
Although many tumors regress in response to neoadjuvant chemotherapy, residual tumor cells are detected in most cancer patients post-treatment. These residual tumor cells are thought to remain dormant for years before resuming growth, resulting in tumor ...
Shenduo Li+6 more
doaj +1 more source
Evolution and seed dormancy shape plant genotypic structure through a successional cycle [PDF]
Significance Studies that experimentally examine evolution have provided critical insight in biology. Indeed, rigorous and replicated laboratory experiments have revealed parallel evolution and have proved essential to understanding evolutionary processes. Nonetheless, a typical limitation of such work is the lack of ecological realism.
Anurag A. Agrawal+2 more
openaire +3 more sources
The Dormancy Dilemma: Quiescence versus Balanced Proliferation [PDF]
Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of morbidity and mortality from most solid tumors. Even more daunting is that many of these metastatic deposits silently lie undetected, recurring years to decades ...
Griffith, Linda G.+3 more
core +2 more sources
Microbes as engines of ecosystem function : When does community structure enhance predictions of ecosystem processes? [PDF]
FUNDING This work was supported by NSF grant DEB-1221215 to DN, as well as grants supporting the generation of our datasets as acknowledged in their original publications and in Supplementary Table S1. ACKNOWLEDGMENT We thank the USGS Powell Center ‘Next
Alessandra eLagomarsino+52 more
core +5 more sources
Tumor Dormancy and Slow-Cycling Cancer Cells
Cancer cell heterogeneity is a universal feature of human tumors and represents a significant barrier to the efficacy and duration of anticancer therapies, especially targeted therapeutics. Among the heterogeneous cancer cell populations is a subpopulation of relatively quiescent cancer cells, which are in the G0/G1 cell-cycle phase and refractory to ...
Dean G. Tang+3 more
openaire +4 more sources