Results 61 to 70 of about 18,218 (324)

Long-Term Transcriptional Activity at Zero Growth of a Cosmopolitan Rare Biosphere Member

mBio, 2019
Microbial diversity in the environment is mainly concealed within the rare biosphere (all species with
Bela Hausmann, Claus Pelikan, Thomas Rattei, Alexander Loy, Michael Pester   +4 more
doaj   +1 more source

THE KREBS CYCLE AND CONTROL OF DORMANCY IN THE AGARICUS BISPORUS SPORE [PDF]

New Phytologist, 1976
SUMMARYAlthough defective in the catabolic part of the Krebs cycle, dormant spores of Agaricus bispours display the full complement of the enzymes of this pathway, with the possible exception of the α‐ketoglutarate dehydrogenase complex. This could, however, be functionally replaced by the enzymes of the γ‐aminobutyrate shunt (i.e.
E. J. Stäuble, Dora M. Rast, P. Zobrist
openaire   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of near-isogenic lines targeting a major 4BL QTL responsible for pre-harvest sprouting in wheat

BMC Plant Biology, 2019
Background Resistance to pre-harvest sprouting (PHS) is one of the major objectives in wheat breeding programs. However, the complex quantitative nature of this trait presents challenges when breeding for PHS resistance.
Xingyi Wang, Hui Liu, Guannan Liu, Md Sultan Mia, Kadambot H. M. Siddique, Guijun Yan   +5 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Modeling annual grassland phenology along the central coast of California

Ecosphere, 2017
Grassland phenology is an important component of terrestrial biophysical models, with substantial differences in the cycling of energy, carbon, water, and nutrient fluxes between periods of growth and dormancy.
Ryan R. Bart, Christina L. Tague, Philip E. Dennison   +2 more
doaj   +1 more source

Quantitative response of Alexandrium catenella cyst dormancy to cold exposure [PDF]

, 2018
Author Posting. © The Author(s), 2018. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution.
Anderson, Donald M., Brosnahan, Michael L., Fischer, Alexis D.   +2 more
core   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells

Cell Communication and Signaling
Background Breast cancer cells (BCCs) can remain undetected for decades in dormancy. These quiescent cells are similar to cancer stem cells (CSCs); hence their ability to initiate tertiary metastasis. Dormancy can be regulated by components of the tissue
Alejandra I. Ferrer-Diaz, Garima Sinha, Andrew Petryna, Ruth Gonzalez-Bermejo, Yannick Kenfack, Oluwadamilola Adetayo, Shyam A. Patel, Anupama Hooda-Nehra, Pranela Rameshwar   +8 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source