Results 71 to 80 of about 57,284 (348)

Phenotypic and genotypic characterization of near-isogenic lines targeting a major 4BL QTL responsible for pre-harvest sprouting in wheat

BMC Plant Biology, 2019
Background Resistance to pre-harvest sprouting (PHS) is one of the major objectives in wheat breeding programs. However, the complex quantitative nature of this trait presents challenges when breeding for PHS resistance.
Xingyi Wang, Hui Liu, Guannan Liu, Md Sultan Mia, Kadambot H. M. Siddique, Guijun Yan   +5 more
doaj   +1 more source

Comparative Salt Tolerance Study of Some Acacia Species at Seed Germination Stage [PDF]

Asian Journal of Plant Sciences 15(3-4) (2016) 66-74, 2016
Objective: The purpose of this study was to assess and compare the seed germination response of six Acacia species under different NaCl concentrations in order to explore opportunities for selection and breeding salt tolerant genotypes. Methodology: Germination of seeds was evaluated under salt stresses using 5 treatment levels: 0, 100, 200, 300 and ...
arxiv   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Modeling annual grassland phenology along the central coast of California

Ecosphere, 2017
Grassland phenology is an important component of terrestrial biophysical models, with substantial differences in the cycling of energy, carbon, water, and nutrient fluxes between periods of growth and dormancy.
Ryan R. Bart, Christina L. Tague, Philip E. Dennison   +2 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells

Cell Communication and Signaling
Background Breast cancer cells (BCCs) can remain undetected for decades in dormancy. These quiescent cells are similar to cancer stem cells (CSCs); hence their ability to initiate tertiary metastasis. Dormancy can be regulated by components of the tissue
Alejandra I. Ferrer-Diaz, Garima Sinha, Andrew Petryna, Ruth Gonzalez-Bermejo, Yannick Kenfack, Oluwadamilola Adetayo, Shyam A. Patel, Anupama Hooda-Nehra, Pranela Rameshwar   +8 more
doaj   +1 more source

Population genetic models of dormancy [PDF]

arXiv, 2020
In the present article, we investigate the effects of dormancy on an abstract population genetic level. We first provide a short review of seed bank models in population genetics, and the role of dormancy for the interplay of evolutionary forces in general, before we discuss two recent paradigmatic models, referring to spontaneous resp.
arxiv  

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum [PDF]

, 2008
As nonreplicating tubercle bacilli are tolerant to the cidal action of antibiotics and resistant to multiple stresses, identification of this persister-like population of tubercle bacilli in sputum presents exciting and tractable new opportunities to ...
Alvarez, Anna L Sherratt, Bacon, Beste, Betts, Canetti, Claire Senner, Cole, Connolly, Conway, Daniel, Daugelat, Desjardin, Dhar, Dubnau, Eisen, Fenhalls, Fleischmann, Garnier, Garton, Gomez, Gurdyal S Besra, Jason Hinds, Kalscheuer, Karakousis, Kendall, Kolter, Kumar, Kumar Rajakumar, Larsen, Levin, Mangan, Manganelli, McKinney, Michael R Barer, Mitchison, Mitchison, Monahan, Mukamolova, Munoz-Elias, Murphy, Muttucumaru, Nakagawa, Natalie J Garton, Neyrolles, Olivier Neyrolles, Paramasivan, Park, Philip D Butcher, Rachman, Rajakumar, Rebecca J Smith, Reed, Richard A Adegbola, Rohde, Schnappinger, Shi, Siegele, Simon J Waddell, Sirakova, Smeulders, Sommers, Stewart, Su-Min Lee, Talaat, Talaat, Timm, Van der Geize, Voskuil, Waddell, Waddell, Waddell, Waltermann, Wayne, Wayne, Weichart, Wilkinson, Young   +77 more
core   +4 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Alternating active-dormitive strategy enables overtaking by disadvantaged prey through Parrondo's paradox [PDF]

arXiv, 2021
Dormancy is a costly adaptive strategy that is widespread among living organisms inhabiting diverse environments. We explore mathematical models of predator-prey systems, in order to assess the impact of prey dormancy on the competition between two types of prey, a perennially active (PA) and capable of entering dormancy (dormitive).
arxiv