Results 71 to 80 of about 18,218 (324)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Microbes in nature are limited by carbon and energy: the starving-survival lifestyle in soil and consequences for estimating microbial rates

Frontiers in Microbiology, 2013
Understanding microbial transformations in soils is important for predicting future carbon sequestration and nutrient cycling. This review questions some methods of assessing one key microbial process, the uptake of labile organic compounds.
John Eyres Hobbie, Erik Alan Hobbie
doaj   +1 more source

Dormancy in reproductive vegetative buds in creeping perennials dominating the agricultural weed flora in Scandinavia [PDF]

, 2013
Dormancy, which is the inability to initiate normal growth under otherwise favourable conditions, is an adaptation to escape sprouting prior to seasonal cold temperatures and/or drought in areas where winters are harsh or summers dry.
Liew, Josefine
core  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Adult Human Glioblastomas Harbor Radial Glia-like Cells

Stem Cell Reports, 2020
Summary: Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers.
Rong Wang, Roshan Sharma, Xiaojuan Shen, Ashley M. Laughney, Kosuke Funato, Philip J. Clark, Monika Shpokayte, Peter Morgenstern, Monalisa Navare, Yichi Xu, Shaghayegh Harbi, Ignas Masilionis, Gouri Nanjangud, Yanhong Yang, Gabriel Duran-Rehbein, Martin Hemberg, Dana Pe'er, Viviane Tabar   +17 more
doaj  

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum [PDF]

, 2008
As nonreplicating tubercle bacilli are tolerant to the cidal action of antibiotics and resistant to multiple stresses, identification of this persister-like population of tubercle bacilli in sputum presents exciting and tractable new opportunities to ...
Alvarez, Anna L Sherratt, Bacon, Beste, Betts, Canetti, Claire Senner, Cole, Connolly, Conway, Daniel, Daugelat, Desjardin, Dhar, Dubnau, Eisen, Fenhalls, Fleischmann, Garnier, Garton, Gomez, Gurdyal S Besra, Jason Hinds, Kalscheuer, Karakousis, Kendall, Kolter, Kumar, Kumar Rajakumar, Larsen, Levin, Mangan, Manganelli, McKinney, Michael R Barer, Mitchison, Mitchison, Monahan, Mukamolova, Munoz-Elias, Murphy, Muttucumaru, Nakagawa, Natalie J Garton, Neyrolles, Olivier Neyrolles, Paramasivan, Park, Philip D Butcher, Rachman, Rajakumar, Rebecca J Smith, Reed, Richard A Adegbola, Rohde, Schnappinger, Shi, Siegele, Simon J Waddell, Sirakova, Smeulders, Sommers, Stewart, Su-Min Lee, Talaat, Talaat, Timm, Van der Geize, Voskuil, Waddell, Waddell, Waddell, Waltermann, Wayne, Wayne, Weichart, Wilkinson, Young   +77 more
core   +4 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

The role of Bacillus species in the management of plant-parasitic nematodes

Frontiers in Microbiology
Plant-parasitic nematodes (PPNs), including root-knot nematodes (Meloidogyne spp.), cyst nematodes (Heterodera and Globodera spp.), and other economically significant nematode species, pose severe threats to global agriculture.
Prabhakaran Vasantha-Srinivasan, Ki Beom Park, Kil Yong Kim, Woo-Jin Jung, Yeon Soo Han   +4 more
doaj   +1 more source

Prediction of bacterial functional diversity in clay microcosms

Heliyon, 2021
Microorganisms in clay barriers could affect the long-term performance of waste containers in future deep geological repositories (DGR) for used nuclear fuel through production of corrosive metabolites (e.g., sulfide), which is why clay materials are ...
Alexander A. Grigoryan, Daphne R. Jalique, Simcha Stroes-Gascoyne, Gideon M. Wolfaardt, Peter G. Keech, Darren R. Korber   +5 more
doaj  

Key aspects on the biology, ecology and impacts of johnsongrass [Sorghum halepense (L.) Pers] and the role of glyphosate and non-chemical alternative practices for the management of this weed in Europe [PDF]

, 2019
Sorghum halepense (L.) Pers is a common and noxious worldwide weed of increasing distribution in many European countries. In the present review, information on the biology, ecology, agricultural, economic and environmental impact of johnsongrass is given,
Antonopoulos, Nikolaos, Cheimona, Nikolina, Dogan, Mehmet N., Kanatas, Panagiotis J., Kukorelli, Gabor, Malidza, Goran, Montull Daniel, José María, Peteinatos, Gerasimos, Travlos, Ilias S., Zannopoulos, Stavros   +9 more
core   +3 more sources