Medicinal Research Reviews, EarlyView.ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay +3 more
wiley +1 more source
Mesenchymal stromal cells alleviate neuropathic pain in association with M2 macrophage polarization in dorsal root ganglia and peripheral nerve repair. [PDF]
BMC AnesthesiolChen H +6 more
europepmc +1 more source
Rethinking colitis: MrgprD puts macrophages in the driver's seat†
The Journal of Pathology, EarlyView.Abstract There is increasing evidence to suggest that dysregulated macrophages play an important role in the promotion and maintenance of inflammatory bowel disease (IBD), yet the underlying mechanisms remain unclear. A recent study published by Lv, Xia, Qiao et al in The Journal of Pathology investigated the role of Mas‐related G protein‐coupled ...
Kolja Pocha, Konstantin Bräutigam
wiley +1 more source
Early NGF-TrkA-CGRP signaling-related changes in dorsal root ganglia are associated with mechanical hypersensitivity in a zymosan A-induced SKG model prior to overt arthritis. [PDF]
Neurobiol PainKawata Y, Funakoshi H.
europepmc +1 more source
Percutaneous peripheral nerve stimulation as an ancillary treatment following nerve repair surgery
PM&R, EarlyView.Abstract Background Neuropathic pain after peripheral nerve injury severely degrades quality of life. Peripheral nerve stimulation (PN‐Stim) is cleared by the U.S, Food and Drug Administration for the treatment of acute and chronic pain. This broad indication supports its potential use at the time of peripheral nerve repair in patients reporting ...
Shyam Maisuria +4 more
wiley +1 more source
A computational analysis of biophysical and geometric constraints refutes existing hypotheses of cross-excitation in dorsal root ganglia. [PDF]
Sci RepPerevozniuk D +3 more
europepmc +1 more source
Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases
Phytotherapy Research, EarlyView.Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin +7 more
wiley +1 more source
Paclitaxel induced-mechanical hypersensitivity is associated with time-dependant pro-inflammatory galectin-3<sup>+</sup> macrophages accumulation in the dorsal root ganglia. [PDF]
Neurobiol PainZeboudj L, Malcangio M.
europepmc +1 more source
Dual‐Component Spidroin‐Based Hydrogels: A Mechanically Tunable Platform for 2D and 3D Cell Culture
Small, EarlyView.A dual‐component recombinant spider silk hydrogel platform was developed by combining NT2RepCT with a bioactive vitronectin‐functionalized spidroin domain. The hydrogels self‐assemble under physiological conditions, exhibit tunable mechanical properties, and support 2D and 3D cell culture, providing a versatile platform for mechanobiological studies ...
Sanna Korpela +8 more
wiley +1 more source
Different types of sensory nerve endings in the urinary bladder of mice arising from dorsal root ganglia (DRG) at the thoracolumbar region of vertebral column. [PDF]
Cell Tissue ResSpencer NJ +5 more
europepmc +1 more source