Results 201 to 210 of about 1,233,920 (254)

PTPRK promotes resiniferatoxin-induced postherpetic neuralgia via activating DUSP1/p38 MAPK signaling pathway in dorsal root ganglia. [PDF]

Sci Rep
Zhao Y, Zhang H, Wang Z, Zhu M, Zhang X, Zhang D.   +5 more
europepmc   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy. [PDF]

Mol Ther Methods Clin Dev
Grubor B, Henry KL, Chan SJ, Sheehan M, Shah A, Pellerin A, Bai J, Nadella P, Bommegowda S, Cullen P, Tien E, Chen V, van der Munnik NP, White-Hunt S, Plowey ED, Hamann S, Guise AJ, Xu S, Kirkland M, Doherty J, Lyashenko E, Bhat G, Glajch K, Lo SC, Gianni D, Clarner P, Gagnon J, Chu J, Nambiar K, Lulla M, Zheng F, Weldeab A, Bartlett D, Gutnick A, Reynolds T, Zhu K, Huh D, Carlile TM, Fikes J, Trapa P, Suh J, Morris D, Burkly L.   +42 more
europepmc   +1 more source

Melatonin Mitigates Central Sensitization and Nociplastic Pain in Spinal Cord and Dorsal Root Ganglia of FM Rat Model: Modulation of SIRT1/PGC-1α/MAPK/NF-κB Signaling. [PDF]

J Neuroimmune Pharmacol
Osama J, El-Gazar AA, Ragab GM, El-Sayed NS, Kamel AS.   +4 more
europepmc   +1 more source

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source

Proton Density of the Dorsal Root Ganglia in Classical Fabry Disease: MRI Correlates of Small Fibre Neuropathy. [PDF]

Biomedicines
Weiner S, Perleth S, Schäfer Gómez C, Kampf T, Lau K, Hessenauer F, Homola G, Nordbeck P, Üçeyler N, Sommer C, Pham M, Schindehütte M.   +11 more
europepmc   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Nageotte nodules in human dorsal root ganglia reveal neurodegeneration in diabetic peripheral neuropathy. [PDF]

Nat Commun
Shiers SI, Mazhar K, Wangzhou A, Haberberger R, Lesnak JB, Ezeji NA, Sankaranarayanan I, Tavares-Ferreira D, Cervantes A, Funk G, Horton P, Vines E, Dussor G, Price TJ.   +13 more
europepmc   +1 more source

Newly identified human aminoacyl‐tRNA synthetase complex interacting multifunctional protein 2 (AIMP2) loss‐of‐function mutations cause neurodevelopmental defects linked to cell death in a zebrafish model

The FEBS Journal, EarlyView.
Human AIMP2 mutations lead to severe neurodevelopmental defects and brain atrophy. Using patient‐derived fibroblasts from two individuals, we show decreased AIMP2 protein levels and overall protein synthesis. In a zebrafish loss‐of‐function model, the lack of AIMP2 leads to an increase in cell death and results in smaller brains.
Patrick Mullen, Shenela Lakhani, Joshua Appelbaum, DéJenaé See, Pryce Patterson, Collin M. MacLeod, Alexandra George, Reza Maroofian, Margaret E. Ross, Christopher Francklyn, Alicia M. Ebert   +10 more
wiley   +1 more source

Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain. [PDF]

Proc Natl Acad Sci U S A
Oggero S, Voisin MB, Picco F, Huerta MÁ, Cecconello C, Burgoyne T, Perretti M, Malcangio M.   +7 more
europepmc   +1 more source