Results 1 to 10 of about 11,719,375 (360)

Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution

Pharmaceutics, 2023
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness.
Magdalena Markowicz-Piasecka, Marcin Kubisiak, Katarzyna Asendrych-Wicik, Michał Kołodziejczyk, Joanna Grzelińska, Małgorzata Fabijańska, Tomasz Pietrzak   +6 more
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Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation

Pharmaceutics, 2023
Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high pharmacokinetic ...
Puneet Tyagi, Chandresh Patel, Kimberly Gibson, Fiona MacDougall, Sergei Y. Pechenov, Sarah Will, Jefferson Revell, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Umar Maharoof, Joseph Grimsby, J. Anand Subramony   +12 more
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Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis

Journal of Pharmacological Sciences, 2021
Polygala japonica Houtt. (PJ), a member of the Polygala L. family that is suggested to exhibit detoxification properties in traditional Chinese medicine, is often used to treat upper respiratory tract infections.
Yinan Wu, Hongwei Fu, Xiaobin Yang, Fang Leng, Yadong Huang, Hong Deng, Qi Xiang, Shu Zhang   +7 more
doaj   +1 more source

Analysis of Extemporaneous Prescriptions Prescribed by Dermatovenerologists in Latvia and Comparison with Standardized Compounded Preparation Monographs of Germany and USA

Medicina, 2020
Background and objectives: Even though many industrially manufactured medicines are available, extemporaneous preparations still have their niche in dermatology.
Olga Kiseļova, Baiba Mauriņa, Venta Šidlovska   +2 more
doaj   +1 more source

Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation

mAbs, 2021
Subcutaneous injection of a low volume (100 mg/mL) formulation is an attractive administration strategy for monoclonal antibodies (mAbs) and other biopharmaceutical proteins.
Jack E. Bramham, Stephanie A. Davies, Adrian Podmore, Alexander P. Golovanov   +3 more
doaj   +1 more source

Optimisation study on the flavonoid extraction process from Abrus precatorius leaves and the comparison of total flavonoid content by HPLC and UV

Journal of Holistic Integrative Pharmacy, 2023
Abrus precatorius is a leguminous plant with high medicinal value. Its leaves are rich in flavonoids. There only are limited reports on the extraction process and quality assessment of total flavonoids in Abrus precatorius leaves (APL).
Xujiang Yuan, Cuimin He, Xianmei Xue, Zhike Liang, Yanfen Chen   +4 more
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Experimental determination of the velocity distribution in USP Apparatus 1 (basket apparatus) using Particle Image Velocimetry (PIV)

International Journal of Pharmaceutics: X, 2021
The USP Apparatus 1 (basket apparatus) is commonly used to evaluate the dissolution performance of oral solid dosage forms. The hydrodynamics generated by the basket contributes, in general, to the dissolution rate and hence the dissolution results. Here,
Chadakarn Sirasitthichoke, Satish Perivilli, Mark R. Liddell, Piero M. Armenante   +3 more
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Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

mAbs, 2020
Preferential interactions of excipients with the antibody surface govern their effect on the stability of antibodies in solution. We probed the preferential interactions of proline, arginine.HCl (Arg.HCl), and NaCl with three therapeutically relevant ...
Theresa K. Cloutier, Chaitanya Sudrik, Neil Mody, Sathish A. Hasige, Bernhardt L. Trout   +4 more
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Comparative Survey of People with ME/CFS in Italy, Latvia, and the UK: A Report on Behalf of the Socioeconomics Working Group of the European ME/CFS Research Network (EUROMENE)

Medicina, 2021
Background and Objectives: A comparative survey of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients was carried out in three countries, with the aim of identifying appropriate policy measures designed to alleviate the burden of ...
Elenka Brenna, Diana Araja, Derek F. H. Pheby   +2 more
doaj   +1 more source

Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations

Scientific Reports, 2021
Weak macromolecular interactions assume a dominant role in the behavior of highly concentrated solutions, and are at the center of a variety of fields ranging from colloidal chemistry to cell biology, neurodegenerative diseases, and manufacturing of ...
Arun Parupudi, Sumit K. Chaturvedi, Regina Adão, Robert W. Harkness, Sonia Dragulin-Otto, Lewis E. Kay, Reza Esfandiary, Huaying Zhao, Peter Schuck   +8 more
doaj   +1 more source