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Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation [PDF]

Pharmaceutics, 2023
Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high pharmacokinetic ...
Puneet Tyagi, Chandresh Patel, Kimberly Gibson, Fiona MacDougall, Sergei Y. Pechenov, Sarah Will, Jefferson Revell, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Umar Maharoof, Joseph Grimsby, J. Anand Subramony   +12 more
doaj   +2 more sources

Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution

Pharmaceutics, 2023
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness.
Magdalena Markowicz-Piasecka, Marcin Kubisiak, Katarzyna Asendrych-Wicik, Michał Kołodziejczyk, Joanna Grzelińska, Małgorzata Fabijańska, Tomasz Pietrzak   +6 more
doaj   +1 more source

Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation

mAbs, 2021
Subcutaneous injection of a low volume (100 mg/mL) formulation is an attractive administration strategy for monoclonal antibodies (mAbs) and other biopharmaceutical proteins.
Jack E. Bramham, Stephanie A. Davies, Adrian Podmore, Alexander P. Golovanov   +3 more
doaj   +1 more source

Analysis of Extemporaneous Prescriptions Prescribed by Dermatovenerologists in Latvia and Comparison with Standardized Compounded Preparation Monographs of Germany and USA

Medicina, 2020
Background and objectives: Even though many industrially manufactured medicines are available, extemporaneous preparations still have their niche in dermatology.
Olga Kiseļova, Baiba Mauriņa, Venta Šidlovska   +2 more
doaj   +1 more source

Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

mAbs, 2020
Preferential interactions of excipients with the antibody surface govern their effect on the stability of antibodies in solution. We probed the preferential interactions of proline, arginine.HCl (Arg.HCl), and NaCl with three therapeutically relevant ...
Theresa K. Cloutier, Chaitanya Sudrik, Neil Mody, Sathish A. Hasige, Bernhardt L. Trout   +4 more
doaj   +1 more source

Comparative Survey of People with ME/CFS in Italy, Latvia, and the UK: A Report on Behalf of the Socioeconomics Working Group of the European ME/CFS Research Network (EUROMENE)

Medicina, 2021
Background and Objectives: A comparative survey of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients was carried out in three countries, with the aim of identifying appropriate policy measures designed to alleviate the burden of ...
Elenka Brenna, Diana Araja, Derek F. H. Pheby   +2 more
doaj   +1 more source

Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations

Scientific Reports, 2021
Weak macromolecular interactions assume a dominant role in the behavior of highly concentrated solutions, and are at the center of a variety of fields ranging from colloidal chemistry to cell biology, neurodegenerative diseases, and manufacturing of ...
Arun Parupudi, Sumit K. Chaturvedi, Regina Adão, Robert W. Harkness, Sonia Dragulin-Otto, Lewis E. Kay, Reza Esfandiary, Huaying Zhao, Peter Schuck   +8 more
doaj   +1 more source

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

Scientific Reports, 2021
Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience, especially for chronic diseases.
Sergei Pechenov, Jefferson Revell, Sarah Will, Jacqueline Naylor, Puneet Tyagi, Chandresh Patel, Lihuan Liang, Leo Tseng, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Anish Konkar, Joseph Grimsby, J. Anand Subramony   +13 more
doaj   +1 more source

Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association

Antibodies, 2022
Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products ...
Lok Hin Lui, Christopher F. van der Walle, Steve Brocchini, Ajoy Velayudhan   +3 more
doaj   +1 more source

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)

Medicina, 2021
Background and Objectives: We have conducted a survey of academic and clinical experts who are participants in the European ME/CFS Research Network (EUROMENE) to elicit perceptions of general practitioner (GP) knowledge and understanding of myalgic ...
John Cullinan, Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding   +10 more
doaj   +1 more source