Results 161 to 170 of about 11,719,375 (360)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Bilayered buccal films as child-appropriate dosage form for systemic administration of propranolol.

International journal of pharmaceutics, 2017
A. Abruzzo, F. Nicoletta, F. Dalena, T. Cerchiara, B. Luppi, F. Bigucci   +5 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

An environmental green factorial design/assisted spectrofluorimetric technique for quantitation of citicoline in pharmaceutical dosage form and wastewater. [PDF]

Sci Rep
El-Alamin MMA, Elkhalek OA, Azab MM.
europepmc   +1 more source

Pediatric Drug Development and Dosage Form Design

AAPS PharmSciTech, 2017
Maren Preis, J. Breitkreutz
semanticscholar   +1 more source

RP-HPLC Method Development and Validation for Determination of Eptifibatide Acetate in Bulk Drug Substance and Pharmaceutical Dosage Forms.

, 2017
Maryam Bavand Savadkouhi, Hossein Vahidi, Seyed Abdulmajid Ayatollahi, Shirin Hooshfar, Farzad Kobarfard   +4 more
openalex   +1 more source

SIMULTANEOUS DETERMINATION OF PHENOBARBITAL AND PHENYTOIN BY USING RP-HPLC METHOD IN PURE AND ITS PHARMACEUTICAL DOSAGE FORM

, 2023
Dr Ch. Prasad Yakkala Revanth Subramanyam Sai
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

A sensitive green HPLC-fluorescence method for simultaneous analysis of sacubitril and valsartan in pure forms, pharmaceutical dosage form and human plasma. [PDF]

Sci Rep
Kormod LA, Hegazy MA, Kessiba AM.
europepmc   +1 more source