Results 11 to 20 of about 11,911,230 (418)

Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation

mAbs, 2021
Subcutaneous injection of a low volume (100 mg/mL) formulation is an attractive administration strategy for monoclonal antibodies (mAbs) and other biopharmaceutical proteins.
Jack E. Bramham, Stephanie A. Davies, Adrian Podmore, Alexander P. Golovanov   +3 more
doaj   +1 more source

Analysis of Extemporaneous Prescriptions Prescribed by Dermatovenerologists in Latvia and Comparison with Standardized Compounded Preparation Monographs of Germany and USA

Medicina, 2020
Background and objectives: Even though many industrially manufactured medicines are available, extemporaneous preparations still have their niche in dermatology.
Olga Kiseļova, Baiba Mauriņa, Venta Šidlovska   +2 more
doaj   +1 more source

Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

mAbs, 2020
Preferential interactions of excipients with the antibody surface govern their effect on the stability of antibodies in solution. We probed the preferential interactions of proline, arginine.HCl (Arg.HCl), and NaCl with three therapeutically relevant ...
Theresa K. Cloutier, Chaitanya Sudrik, Neil Mody, Sathish A. Hasige, Bernhardt L. Trout   +4 more
doaj   +1 more source

Comparative Survey of People with ME/CFS in Italy, Latvia, and the UK: A Report on Behalf of the Socioeconomics Working Group of the European ME/CFS Research Network (EUROMENE)

Medicina, 2021
Background and Objectives: A comparative survey of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients was carried out in three countries, with the aim of identifying appropriate policy measures designed to alleviate the burden of ...
Elenka Brenna, Diana Araja, Derek F. H. Pheby   +2 more
doaj   +1 more source

Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations

Scientific Reports, 2021
Weak macromolecular interactions assume a dominant role in the behavior of highly concentrated solutions, and are at the center of a variety of fields ranging from colloidal chemistry to cell biology, neurodegenerative diseases, and manufacturing of ...
Arun Parupudi, Sumit K. Chaturvedi, Regina Adão, Robert W. Harkness, Sonia Dragulin-Otto, Lewis E. Kay, Reza Esfandiary, Huaying Zhao, Peter Schuck   +8 more
doaj   +1 more source

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

Scientific Reports, 2021
Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience, especially for chronic diseases.
Sergei Pechenov, Jefferson Revell, Sarah Will, Jacqueline Naylor, Puneet Tyagi, Chandresh Patel, Lihuan Liang, Leo Tseng, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Anish Konkar, Joseph Grimsby, J. Anand Subramony   +13 more
doaj   +1 more source

Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association

Antibodies, 2022
Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products ...
Lok Hin Lui, Christopher F. van der Walle, Steve Brocchini, Ajoy Velayudhan   +3 more
doaj   +1 more source

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)

Medicina, 2021
Background and Objectives: We have conducted a survey of academic and clinical experts who are participants in the European ME/CFS Research Network (EUROMENE) to elicit perceptions of general practitioner (GP) knowledge and understanding of myalgic ...
John Cullinan, Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding   +10 more
doaj   +1 more source

The Extent of Extemporaneous Preparation and Regulatory Framework of Extemporaneous Compounding in Latvia

Medicina, 2019
Background and objectives: Extemporaneous preparations are pharmaceutical preparations individually prepared for a specific patient or patient group, but also high-risk products accompanied by doubts regarding their safety and quality.
Olga Kiseļova, Baiba Mauriņa, Venta Šidlovska, Jānis Zvejnieks   +3 more
doaj   +1 more source

Design of targeted dosage form of ofloxacin+ [PDF]

Journal of the Serbian Chemical Society, 2006
The targeted pro-drug is a classical pro-drug design often representing a non-specific chemical approach to mask undesirable drug properties, such as limited bioavailability, lack of site specificity, and chemical instability. On the other hand, targeted
Shahar Yar M., Siddiqui Ahamed A., Ali Ashraf M., Manogran E.   +3 more
doaj   +3 more sources