Results 11 to 20 of about 11,797,694 (349)
Chipping away at gamma-H2AX foci [PDF]
, 2009 The mammalian histone H2AX protein functions as a dosage-dependent genomic caretaker and tumor suppressor. Phosphorylation of H2AX to form gamma-H2AX in chromatin around DNA double strand breaks (DSBs) is an early event following induction of these ...
Bassing, Craig H +3 more
core +1 more source
MELATONIN DOSAGE FORMS WITH AN EMPHASIS ON MODIFIED RELEASE DOSAGE FORMS
, 2022 The first objective of this study was to evaluate melatonin properties related with the release behavior of this substance in oral controlled release tablets. Melatonin was found as a highly soluble substance with a micronized particle size (D50=4.1µm) and recrystallization in the same polymorphic form.
openaire +1 more source
Expert Opinion on Drug Delivery, 2018 Introduction: The development of oral sustained release dosage forms has been a longstanding goal due to the potential for ease of administration, improved pharmacokinetics, reduced dosing frequency, and improved adherence.
David H. Altreuter +5 more
semanticscholar +1 more source
Journal of Applied Pharmaceutical Sciences, 2018 © 2018 Chairany Siregar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License -NonCommercial-ShareAlikeUnported License (http://creativecommons.org/licenses/by-nc-sa/3.0/).
C. Siregar, S. Martono, A. Rohman
semanticscholar +1 more source
An epidemiological assessment of lens opacifications that impaired vision in patients injected with radium-224 [PDF]
, 1988 The incidence of lens opacifications that impaired vision (cataract) was analyzed among 831 patients who were injected with known dosages of 224Ra in Germany shortly after World War II.
Chmelevsky, D. +4 more
core +1 more source
A REVIEW ON CIPROFLOXACIN: DOSAGE FORM PERSPECTIVE
International Journal of Applied Pharmaceutics, 2018 Ciprofloxacin (CF) is one of the topmost selling antibiotics and it is available at a cheap cost which is used to treat many bacterial infections. Many research scientists are working on this drug for various applications on different drug delivery ...
M. Vidyavathi, G. Srividya
semanticscholar +1 more source
A survey of Top 200 Drugs—Inconsistent Practice of Drug Strength Expression for Drugs Containing Salt Forms [PDF]
, 2012 Many ionizable drugs are developed and marketed as salt forms. However, there are no clear US regulatory guidelines on drug strength labeling for salts. The strengths of some drugs are expressed as salts and some as free acids/bases.
Prohotsky, Daniel, Zhao, Fang
core +2 more sources
Quality of medicines commonly used in the treatment of soil transmitted helminths and Giardia in Ethiopia: a nationwide survey [PDF]
, 2014 Background: The presence of poor quality medicines in the market is a global threat on public health, especially in developing countries. Therefore, we assessed the quality of two commonly used anthelminthic drugs [mebendazole (MEB) and albendazole (ALB)]
D'Hondt, Matthias +9 more
core +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source