Results 11 to 20 of about 11,719,375 (360)

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

Scientific Reports, 2021
Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience, especially for chronic diseases.
Sergei Pechenov, Jefferson Revell, Sarah Will, Jacqueline Naylor, Puneet Tyagi, Chandresh Patel, Lihuan Liang, Leo Tseng, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Anish Konkar, Joseph Grimsby, J. Anand Subramony   +13 more
doaj   +1 more source

Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association

Antibodies, 2022
Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products ...
Lok Hin Lui, Christopher F. van der Walle, Steve Brocchini, Ajoy Velayudhan   +3 more
doaj   +1 more source

The Extent of Extemporaneous Preparation and Regulatory Framework of Extemporaneous Compounding in Latvia

Medicina, 2019
Background and objectives: Extemporaneous preparations are pharmaceutical preparations individually prepared for a specific patient or patient group, but also high-risk products accompanied by doubts regarding their safety and quality.
Olga Kiseļova, Baiba Mauriņa, Venta Šidlovska, Jānis Zvejnieks   +3 more
doaj   +1 more source

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)

Medicina, 2021
Background and Objectives: We have conducted a survey of academic and clinical experts who are participants in the European ME/CFS Research Network (EUROMENE) to elicit perceptions of general practitioner (GP) knowledge and understanding of myalgic ...
John Cullinan, Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding   +10 more
doaj   +1 more source

Knowledge about Disease, Medication Therapy, and Related Medication Adherence Levels among Patients with Hypertension

Medicina, 2019
Background and Objectives: A particular problem in cardiology is poor adherence to pharmacological treatment among patients with hypertension. It is known that approximately half of these patients do not use their medications as prescribed by their ...
Anna Gavrilova, Dace Bandere, Ieva Rutkovska, Dins Šmits, Baiba Mauriņa, Elita Poplavska, Inga Urtāne   +6 more
doaj   +1 more source

A Multiple Unit Abuse-deterrent Dosage Form Based on Sodium Alginate

European Pharmaceutical Journal, 2023
There are several approaches for the formulation of abuse-deterrent, tamper-resistant, or alcohol-resistant dosage forms. This work is specifically focused on the formulation of microforms and multiple unit dosage forms with the mentioned resistant ...
Papadakos M., Špaglová M., Čuchorová M., Hanko M.   +3 more
doaj   +1 more source

Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics

Pharmaceutics, 2019
Embedded three-dimensional printing (e-3DP) is an emerging method for additive manufacturing where semi-solid materials are extruded within a solidifying liquid matrix. Here, we present the first example of employing e-3DP in the pharmaceutical field and
Katarzyna Rycerz, K. Stępień, Marta Czapiewska, B. Arafat, R. Habashy, Abdullah Isreb, M. Peak, M. Alhnan   +7 more
semanticscholar   +1 more source

Design of targeted dosage form of ofloxacin+ [PDF]

Journal of the Serbian Chemical Society, 2006
The targeted pro-drug is a classical pro-drug design often representing a non-specific chemical approach to mask undesirable drug properties, such as limited bioavailability, lack of site specificity, and chemical instability. On the other hand, targeted
Shahar Yar M., Siddiqui Ahamed A., Ali Ashraf M., Manogran E.   +3 more
doaj   +3 more sources

Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions

mAbs, 2020
Monoclonal antibodies are a class of biotherapeutics used for an increasing variety of disorders, including cancer, autoimmune, neurodegenerative, and viral diseases.
Sumit K. Chaturvedi, Arun Parupudi, Kristian Juul-Madsen, Ai Nguyen, Thomas Vorup-Jensen, Sonia Dragulin-Otto, Huaying Zhao, Reza Esfandiary, Peter Schuck   +8 more
doaj   +1 more source

Stability indicating RP-HPLC technique for simultaneous estimation of nirmatrelvir and ritonavir in their new copackaged dosage form for COVID-19 treatment. [PDF]

Sci Rep
Yassin MG, Roshdy A, Marie AA.
europepmc   +3 more sources