Results 31 to 40 of about 687,381 (307)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Gene expression in Leishmania is regulated predominantly by gene dosage [PDF]

, 2017
Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here,
Berriman, Matthew, Beverley, Stephen M., Cotton, James A., Durrant, Caroline, Grigg, Michael E., Iantorno, Stefano A., Khan, Asis, Myler, Peter, Ouellette, Marc, Sacks, David L., Sanders, Mandy J., Warren, Wesley C., Weiss, Louis M.   +12 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Utilizing RxNorm to Support Practical Computing Applications: Capturing Medication History in Live Electronic Health Records

, 2012
RxNorm was utilized as the basis for direct-capture of medication history data in a live EHR system deployed in a large, multi-state outpatient behavioral healthcare provider in the United States serving over 75,000 distinct patients each year across 130
Bodenreider, Bodenreider, Casey C. Bennett, Cover, Fung, Henkel, Hernandez, Hoffer, Kobayashi, Levin, Nelson, O’Neill, Palchuk, Pathak, Richesson, Ruch, Russell, Shannon, Szegedi, Wade, Zeng   +20 more
core   +1 more source

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]

, 2017
Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh, Chen, Yanbin, Chin, Adave, Hirabayashi, Yoko, Hirata, Tsuyoshi, Nagarajan, Narayani, Naito, Daichi, Oka, Shin-Ichi, Sadoshima, Junichi, Saito, Toshiro, Schesing, Kevin, Sciarretta, Sebastiano, Shao, Dan, Suzuki, Wataru, Yaginuma, Hiroaki, Yodoi, Junji, Zhai, Peiyong   +16 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Systematic review of the safety of medication use in inpatient, outpatient and primary care settings in the Gulf Cooperation Council countries [PDF]

, 2018
Background Errors in medication use are a patient safety concern globally, with different regions reporting differing error rates, causes of errors and proposed solutions.
Abu Yassin, Abushaiqa, Ackroyd-Stolarz, Al Anany, Al Anazi, Al Hamid, Al Khaja, Al Khaja, Al Khaja, Al Khaja, Al Khaja, Al Odhayani, Al Rahbi, Al Shahaibi, Al-Arifi, Al-Arifi, Al-Dhawailie, Al-Ghamdi, Al-Hussein, Al-Jazairi, Al-Jeraisy, Al-Khani, Al-Olah, Al-Omar, Al-Rashdi, Al-Rowibah, Al-Tajir, Alakhali, Alanazi, Albarrak, Alghamdy, Aljadhey, Aljadhey, Aljadhey, Aljamal, Allan, Almazrou, Alshaikh, Alsulaimi, Altebenaui, American Geriatrics Society Beers Criteria Update Expert Panel, Arabi, Aseeri, ASHP, Bates, Bryony Dean Franklin, Cohen, Dean, Dean, Dean, Dean, Dibbi, Elnour, Ferner, Fick, Flynn, Flynn, Gandhi, Ghaleb, Ghaleb, Hemida, Hepler, Hisham Saad Aljadhey, Hooper, Insley, Irshaid, Jamilah Alsaidan, Jane Portlock, Jha, Jha, Kaushal, Kheir, Khoja, Landis, Lisby, Mahmoud, McLeod, McPhillips, Mendonca, Miller, Mitwally, Morimoto, Morimoto, Nada Atef Shebl, Naranjo, Nebeker, Neville, Rancourt, Rashed, Rashed, Rehmani, Sadat-Ali, Shaughnessy, Sonallah, WHO, World Bank   +95 more
core   +3 more sources

Concentrate for Intravesical Solution Dosage Form [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Intravesical Suspension Dosage Form [PDF]

, 2020
National Cancer Institute
openalex   +1 more source