Results 121 to 130 of about 978,397 (252)

Population pharmacokinetics [PDF]

Vojnosanitetski Pregled, 2005
Milovanović Jasmina R., Janković Slobodan M.   +1 more
doaj   +1 more source

The association between birthweight and adult lung function: insights from the UK Biobank

BMC Pulmonary Medicine
Background The potential association between birthweight and adult lung function has been postulated, yet the precise nature of this association in later life remains inconclusive.
Yu Wang, Yuanyi Zhang, Yacong Bo, Pengfei Li, Tianci Jiang, Yue Li, Zhe Cheng, Yongjian Zhu   +7 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Application of the Linear-Quadratic model to targeted radionuclide therapy

, 2011
PhDThe principal aim of this work was to test the hypothesis that the Linear-Quadratic (LQ) model of cell survival, developed for external beam radiotherapy (EBRT), could be extended to targeted radionuclide therapy (TRT) in order to predict dose ...
Murray, Iain
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Diltiazem-cyclosporin pharmacokinetic interaction - dose-response relationship.

, 1997
Aims: To study the dose-response relationship of the pharmacokinetic interaction between diltiazem and cyclosporin in kidney transplant recipients. Methods: Eight stable kidney transplant recipients maintained on cyclosporin but not taking diltiazem ...
Mathew, T., Morris, R., Jones, T.
core   +1 more source

Dose–Response Relationship Between Aircraft Noise Exposure and Community Annoyance: A Case Study of Hangzhou Xiaoshan International Airport

Noise and Health
Objective:With increasing air traffic, aircraft noise pollution near Hangzhou Xiaoshan International Airport has intensified, raising concerns about community annoyance.
Jiakang Lv, Yinuo Chen, Mengze Yang, Qihan Zeng, Qianqian Zhou, Jiabin Chen, Yong Liu   +6 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Defining the Optimal Selenium Dose for Prostate Cancer Risk Reduction: Insights from the U-Shaped Relationship between Selenium Status, DNA Damage, and Apoptosis

, 2010
Our work in dogs has revealed a U-shaped dose response between selenium status and prostatic DNA damage that remarkably parallels the relationship between dietary selenium and prostate cancer risk in men, suggesting that more selenium is not necessarily ...
Huiping Xu, David J. Waters, Seema S. Kengeri, Emily C. Chiang, Gerald F. Combs, J. Steven Morris, David G. Bostwick, Shuren Shen   +7 more
core   +1 more source