Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang +16 more
wiley +1 more source
Dose-response relationship between Life's Essential 8 score and COPD risk: the NHANES cohort study 2007-2018. [PDF]
Huang Q +5 more
europepmc +1 more source
AI is transforming the research paradigm of battery materials and reshaping the entire landscape of battery technology. This comprehensive review summarizes the cutting‐edge applications of AI in the advancement of battery materials, underscores the critical challenges faced in harnessing the full potential of AI, and proposes strategic guidance for ...
Qingyun Hu +5 more
wiley +1 more source
Exploring the Dose-Response Relationship Between Nature-Based Outdoor Activities, Nature Connectedness and Social Health In Adolescents: A Quasi-Experimental Controlled Study. [PDF]
Choe EY, Lee JY, Zhu S.
europepmc +1 more source
Additive manufacturing is expanding beyond mechanical prosthetics into microelectronic implants. This work presents a diamond‐titanium hybrid that enables wireless power transfer, localized heating, and flow sensing. The use of additive manufacturing combined with the biocompatibility of the diamond‐titanium hybrid material paves the way toward new ...
Joshua Zarins +9 more
wiley +1 more source
Changes in lactate concentration are accompanied by opposite changes in the pattern of fat oxidation: Dose-response relationship. [PDF]
Benítez-Muñoz JA +6 more
europepmc +1 more source
This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...
Siyuan Tao +9 more
wiley +1 more source
Dose-response relationship between sedentary time and anxiety and the moderating effect of a 10-min walk: a cross-sectional study. [PDF]
Tian Z +5 more
europepmc +1 more source
Advances in integrating artificial intelligence into 3D bioprinting are systematically reviewed here. Machine learning, computer vision, robotics, natural language processing, and expert systems are examined for their roles in optimizing bioprinting parameters, real‐time monitoring, quality control, and predictive maintenance.
Joao Vitor Silva Robazzi +10 more
wiley +1 more source
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source

