Model-Informed Paradigm in Drug Development-An End-To-End Case Study From Upadacitinib Development. [PDF]
Bhatnagar S+5 more
europepmc +1 more source
A simple, cleanroom‐free method produces flexible mini‐coils using automated blade cutting. The process is fast, low‐cost, and supports diverse materials. The coils show strong durability and performance under repeated bending. Demonstrated use in resistor‐inductor filters and magnetic nanoparticle control proves their adaptability.
Changhao Ge+5 more
wiley +1 more source
Determination of 5-Fluorouracil in Dried Blood Spots for Therapeutic Drug Monitoring and Adverse Event Assessment in Breast Cancer Patients. [PDF]
Hanifah M, Harahap Y, Purwanto DJ.
europepmc +1 more source
This study introduces an extracorporeal hemoperfusion system incorporating porous microbeads embedded with autocatalytic ceria nanoparticles (CeNPs) for targeted reactive oxygen species (ROS) scavenging in septic shock. The blood‐compatible hemoperfusion cartridge demonstrated significant improvements in survival, hemodynamic stability, and organ ...
Pilseon Im+10 more
wiley +1 more source
Low-Dose Alfentanil Effectively Reduces the ED50 of Remimazolam for Loss of Consciousness in Pediatric Patients Undergoing General Anesthesia: A Study Using Up-and-Down Sequential Allocation Method. [PDF]
Shi X+7 more
europepmc +1 more source
3D Printed Ultra‐Fast Plastic Scintillators Based on Perovskite‐Photocurable Polymer Composite
The demand for radiation detection is increasing in a number of fields, including high‐energy physics, medical imaging, and homeland security. This study serves to demonstrate the potential for the fabrication of fast perovskite‐based scintillators with complex shapes via stereolithographic additive manufacturing, representing a new path toward the ...
Antonella Giuri+16 more
wiley +1 more source
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen+13 more
wiley +1 more source
Predicting Δ-9-Tetrahydrocannabinol-Induced Psychoactive and Cognitive Effects: A PBPK-PD Approach to Quantifying Feeling High and Reduced Alertness. [PDF]
Qian L, Zhou Z.
europepmc +1 more source
A lack of standard approaches for testing and reporting the performance of metal halide perovskites and organic semiconductor radiation detectors has resulted in inconsistent interpretation of performance parameters, impeding progress in the field. This Perspective recommends key metrics and experimental details, which are suggested for reporting in ...
Jessie A. Posar+8 more
wiley +1 more source
Using circulating tumor DNA as a novel biomarker of efficacy for dose-finding designs in oncology. [PDF]
Chen X, Mozgunov P, Baird RD, Jaki T.
europepmc +1 more source