Results 211 to 220 of about 925,610 (310)

Super-high tumor mutational burden predicts complete remission following immunotherapy: from Peto's paradox to druggable cancer hallmark. [PDF]

J Immunother Cancer
Zheng M.
europepmc   +1 more source

Global Trends in Risk Factors for Low Back Pain: An Analysis of the Global Burden of Disease Study Data From 1990 to 2021

Arthritis Care &Research, EarlyView.
Objective The increasing burden associated with low back pain (LBP) is a critical issue. This is a novel analysis of trends in risk factors for LBP aiming to identify risk factors that require further attention or consideration in global policies to reduce the burden of LBP.
Katharine E. Roberts, Manuela L. Ferreira, Paula R. Beckenkamp, Sneha Nicholson, Lyn March, Paulo H. Ferreira   +5 more
wiley   +1 more source

The cardiac work-loop technique:An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles [PDF]

, 2020
AJ Taberner, AM Aylin, AW Tank, CW Scott, D Burkhoff, D Mehra, DA Eisner, DM Bers, DR Varma, E Takimoto, FG Spinale, H Lüllman, J Layland, J Layland, J Layland, J Layland, J Layland, J Tallis, JI Schwartz, JJ Lynch, JL Holtzman, JR Blinks, JS Landzberg, K Noguchi, K Sagawa, KC Vinnakota, L Batista, L Brown, L Butler, L Guo, LJ Mellors, M Eichelbaum, M Gharanei, MA Rosic, ME Conolly, MF Peters, MS Parmacek, P Bergson, R Beigel, R Josephson, R Lewis, R Seifert, R Zhang, RA Nishimura, RC Heel, RD Olson, RK Josephson, RM Bell, RS James, T Akera, T Bombardini, T Delhaas, VJ Caiozzo, W Kerns, W Semafuko, WA Catterall, Y Kihara   +56 more
core   +1 more source

Response to Professor Hu Jinyu's Letter [Response to Letter]. [PDF]

Drug Des Devel Ther
Kang X, Jin, Ji H, An X, Zhang Y, Duan L, Yang C, Zhou R, Duan Y, Zhang Y, Sun Y, Jiang L, Lian F, Tong X.   +13 more
europepmc   +1 more source

Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra‐Articular Injections of Biologic Agents

Arthritis Care &Research, EarlyView.
Objective Patients with knee osteoarthritis rely on symptomatic treatments, in which up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (eg, biologics vs nonbiologic injection) and route of administration (eg, intra‐articular vs topical vs oral).
Johanna M. Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian, Samuel R. Ward   +5 more
wiley   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

The Effect of Nitrous Oxide on the Dose-Response Relationship of Rocuronium

Anesthesia and Analgesia, 2005
A. Kopman, W. Chin, J. Moe, R. Malik
semanticscholar   +1 more source

Using Pharmacokinetic and Pharmacodynamic Analysis to Optimize the Dosing Regimens of Fanastomig (EMB-02) in Patients With Advanced Solid Tumors. [PDF]

CPT Pharmacometrics Syst Pharmacol
Jiang C, Ren F, Zhang M, Lu Q, Zeng S, Yang G, Zhu Y.   +6 more
europepmc   +1 more source

Ageism in Rheumatology: the Healthcare Professional's Perspective

Arthritis Care &Research, Accepted Article.
Objective Ageism (age‐based stereotypes, prejudice, or discrimination) is prevalent and linked to prolonged disability and reduced lifespan in older adults. Little is known about ageism within rheumatology. This study explores the healthcare professional's (HCP) perception of the care of older adults and how ageist attitudes or perspectives may impact ...
Aaron P. Smith, Pooja M. Achanta, Jiha Lee, Namrata Singh, Una E. Makris   +4 more
wiley   +1 more source