Results 211 to 220 of about 734,043 (307)

A digital twin of glimepiride for personalized and stratified diabetes treatment. [PDF]

Front Pharmacol
Elias M, König M.
europepmc   +1 more source

Digital behavioral therapy improves outcome in patients with axial spondyloarthritis and persistent pain: a randomized controlled trial

Arthritis Care &Research, Accepted Article.
Objectives Axial spondyloarthritis (axSpA) is often associated with persistent pain despite effective anti‐inflammatory treatment. Digital health applications (DHA) provide innovative approaches to address multidimensional aspects of persistent pain through psychological and behavioral strategies. The aim of this study was to assess the impact of a DHA
David Kiefer, Yade Sonkaya, Dietmar Krause, Markus Voglau, Bernhard Mintrop, Imke Redeker, Xenofon Baraliakos, Uta Kiltz   +7 more
wiley   +1 more source

Testing for Similarity of Dose Response in Multiregional Clinical Trials. [PDF]

Stat Med
Dette H, Koletzko L, Bretz F.
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Hypertension
Argeros Z, Xu X, Bhandari B, Harris K, Touyz RM, Schutte AE.   +5 more
europepmc   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Comparison of interpatient and intrapatient variability in doxorubicin exposure using a validated limited sampling model in dogs with cancer. [PDF]

Vet Oncol
Veluvolu SM, Rebhun RB, Kim J, Wittenburg LA.   +3 more
europepmc   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Continuous-Time Markov Population PK/PD Modeling of Longitudinal EASI Categorical Score in Atopic Dermatitis Treated With Rocatinlimab, an Anti-OX40 Monoclonal Antibody. [PDF]

CPT Pharmacometrics Syst Pharmacol
Okada H, Liao S, Khouri L, Liao L, Hruska MW, Nagata Y, Hasegawa M, Gewitz A, Marsteller D.   +8 more
europepmc   +1 more source

Microscale 3D Printed Pillars and Porous Polymeric Structures: Manufacturability and Micromechanics

Advanced Engineering Materials, EarlyView.
This work demonstrates how two‐photon polymerization enables the fabrication of microscale solid and porous structures from IP‐Q, IP‐S, and IP‐PDMS resins. Combining morphological and mechanical characterization, the study provides the first systematic insights into IP‐Q mechanics and reveals how processing parameters affect structure and stiffness ...
Aikaterini Isaakidou, Mahya Ganjian, Vahid Moosabeiki, Marius Alexander Leeflang, Mahdiyeh Nouri Goushki, Pouyan Esmailzadeh Boukany, Maria Wątroba, Alexander Groetsch, Jakob Schwiedrzik, Mohammad Javad Mirzaali, Iulian Apachitei, Lidy Elena Fratila‐Apachitei, Amir Abbas Zadpoor   +12 more
wiley   +1 more source