Results 211 to 220 of about 4,085,456 (259)

Quantitative Cherenkov-excited fluorescence emission dosimetry for HDR Co-60 brachytherapy: Calibration and planar validation against TPS. [PDF]

J Appl Clin Med Phys
Yedekci Y, Enkavi MF, Yildiz F.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Dose-Response Meta-Analysis: A Quantitative Perspective on Rheumatic Diseases. [PDF]

Int J Rheum Dis
Lei Y, Tang T, Du A, Xu L, Tung WT.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Feasibility of AI-Denoised Ultra-Low-Dose CT for Detection of Acute Pelvic and Hip Fractures: A Pilot Multi-Reader Study. [PDF]

Diagnostics (Basel)
Nguyen D, Shiang T, Ge C, Watts G, Sereni C, Radcliffe D, Kotecha H, Nunez GS, Kim YH.   +8 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations. [PDF]

Drug Des Devel Ther
Zhang J, Wang X, Xu H, Zang A, Zhao J, Chen J, Lei R, Zhang Z, Hao C, Liu Y, Zhou R, He L, Sun T, Ouyang Q, Chen S, Xu J, Zhou W, Shi Y, Tong Z.   +18 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703). [PDF]

JAMA
Ng K, Ou FS, Zemla T, Jackson NA, Kalyan A, Devoe C, Shusterman M, Vijayvergia N, Wu CS, Cohen SA, Pulsipher S, Shergill A, Watson Y, Kleiber B, Lee M, Kohn CG, Thalappillil JS, Schwartz LH, Zuckerman D, Hollis BW, O'Reilly EM, Meyerhardt JA.   +21 more
europepmc   +1 more source