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Naloxone reversal of clonidine toxicity: dose, dose, dose

Clinical Toxicology, 2018
Following clonidine ingestion, naloxone is seldom administered as it is considered ineffective in reversing somnolence, bradycardia, or hypotension. However, this conclusion has been based on administration of small doses (2 mg or less) of naloxone. The somnolence is frequently treated with endotracheal intubation (ETI), a procedure with significant ...
Donna L, Seger, Justin K, Loden
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Dose

Radiation Research, 1994
The universal use of dose as a normalizing parameter in radiobiology is based entirely on the availability of measuring instruments. It is a poor basis for predicting or understanding the relationship between an irradiation and the resulting end point. Energy deposited is not the cause of an interaction. It is a secondary effect.
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Cytarabine: Low-Dose, High-Dose, No Dose?

New England Journal of Medicine, 1983
Cytarabine is the mainstay of current treatment for acute myeloblastic leukemia and is associated with an expected remission rate of more than 50 per cent.
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Dose, dose, dose, but where is the patient dose?

Radiation Protection Dosimetry
Abstract The article reviews the historical developments in radiation dose metrices in medical imaging. It identifies the good, the bad, and the ugly aspects of current-day metrices. The actions on shifting focus from International Commission on Radiological Protection (ICRP) Reference-Man–based population-average phantoms to patient ...
Madan M Rehani, Xie George Xu
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