Results 11 to 20 of about 195,339 (270)

Comparison of different methods for post-therapeutic dosimetry in [177Lu]Lu-PSMA-617 radioligand therapy

EJNMMI Physics, 2021
Background Dosimetry is of high importance for optimization of patient-individual PSMA-targeted radioligand therapy (PSMA-RLT). The aim of our study was to evaluate and compare the feasibility of different approaches of image-based absorbed dose ...
Florian Rosar, Niklas Schön, Hendrik Bohnenberger, Mark Bartholomä, Tobias Stemler, Stephan Maus, Fadi Khreish, Samer Ezziddin, Andrea Schaefer-Schuler   +8 more
doaj   +2 more sources

EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands

European Journal of Nuclear Medicine and Molecular Imaging, 2022
The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance to scientists and clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications,
K. Sjögreen Gleisner, N. Chouin, P. M. Gabiña, F. Cicone, S. Gnesin, C. Stokke, M. Konijnenberg, Marta Cremonesi, F. Verburg, P. Bernhardt, U. Eberlein, J. Gear   +11 more
semanticscholar   +1 more source

Ultra‐high dose rate dosimetry: Challenges and opportunities for FLASH radiation therapy

Medical Physics (Lancaster), 2022
The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors currently in use suffer from saturation effects under UHDR regimes, requiring
F. Romano, C. Bailat, P. G. Jorge, M. Lerch, A. Darafsheh   +4 more
semanticscholar   +1 more source

MIRD Pamphlet No. 28, Part 1: MIRDcalc—A Software Tool for Medical Internal Radiation Dosimetry

Journal of Nuclear Medicine, 2023
Medical internal radiation dosimetry constitutes a fundamental aspect of diagnosis, treatment, optimization, and safety in nuclear medicine. The MIRD committee of the Society of Nuclear Medicine and Medical Imaging developed a new computational tool to ...
A. Kesner, L. Carter, Juan C. Ocampo Ramos, D. Lafontaine, E. Olguin, Justin L Brown, Bonnie President, D. Jokisch, D. Fisher, W. Bolch   +9 more
semanticscholar   +1 more source

Dosimetry in Radiopharmaceutical Therapy

Journal of Nuclear Medicine, 2022
The application of radiopharmaceutical therapy for the treatment of certain diseases is well established, and the field is expanding. New therapeutic radiopharmaceuticals have been developed in recent years, and more are in the research pipeline ...
Joe O’Donoghue, Pat B Zanzonico, J. Humm, A. Kesner   +3 more
semanticscholar   +1 more source

Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial.

The Lancet Gastroenterology and Hepatology, 2020
BACKGROUND All randomised phase 3 studies of selective internal radiation therapy for advanced hepatocellular carcinoma published to date have reported negative results. However, these studies did not use personalised dosimetry.
E. Garin, L. Tselikas, B. Guiu, J. Chalaye, J. Edeline, T. de Baère, E. Assenat, V. Tacher, C. Robert, Marie Terroir-Cassou-Mounat, D. Mariano-Goulart, G. Amaddeo, X. Palard, A. Hollebecque, M. Kafrouni, H. Regnault, K. Boudjema, S. Grimaldi, M. Fourcade, H. Kobeiter, E. Vibert, S. le Sourd, L. Piron, D. Sommacale, S. Laffont, B. Campillo-Gimenez, Y. Rolland   +26 more
semanticscholar   +1 more source

Prostate-Specific Membrane Antigen Radioligand Therapy Using 177Lu-PSMA I&T and 177Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer: Comparison of Safety, Biodistribution, and Dosimetry

Journal of Nuclear Medicine, 2021
Visual Abstract The objective of this study was to determine the safety, kinetics, and dosimetry of the 177Lu-labeled prostate-specific membrane antigen (PSMA) small molecules 177Lu-PSMA I&T and 177Lu-PSMA-617 in a large cohort of patients with ...
C. Schuchardt, Jingjing Zhang, H. Kulkarni, Xiaoyuan Chen, D. Mueller, R. Baum   +5 more
semanticscholar   +1 more source

EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres

EJNMMI Physics, 2021
The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in 90 Y microsphere liver radioembolization.
C. Chiesa, Katarina Sjogreen-Gleisner, S. Walrand, L. Strigari, G. Flux, J. Gear, C. Stokke, P. M. Gabiña, P. Bernhardt, M. Konijnenberg   +9 more
semanticscholar   +1 more source

Report of AAPM Task Group 155: Megavoltage photon beam dosimetry in small fields and non‐equilibrium conditions

Medical Physics (Lancaster), 2021
Small‐field dosimetry used in advance treatment technologies poses challenges due to loss of lateral charged particle equilibrium (LCPE), occlusion of the primary photon source, and the limited choice of suitable radiation detectors.
Indra J. Das, P. Francescon, Jean M. Moran, A. Ahnesjö, M. Aspradakis, Chee-Wai Cheng, G. Ding, John D. Fenwick, M. Saiful Huq, M. Oldham, C. Reft, Otto A. Sauer   +11 more
semanticscholar   +1 more source

Dosimetry in radionuclide therapy: the clinical role of measuring radiation dose.

The Lancet Oncology, 2022
Radionuclide therapy is a rapidly expanding oncological treatment method. Overwhelmingly, the application of radionuclide therapy in clinical practice relies on fixed or empirical dosing strategies.
Courtney Lawhn-Heath, T. Hope, J. Martinez, E. K. Fung, Jaehoon Shin, Y. Seo, R. Flavell   +6 more
semanticscholar   +1 more source