Results 101 to 110 of about 3,798,723 (244)

Optimal Dosing for Targeted Therapies in Oncology: Drug Development Cases Leading by Example

Clinical Cancer Research, 2015
One of the key objectives of oncology first-in-human trials has often been to establish the maximum tolerated dose (MTD). However, targeted therapies might not exhibit dose-limiting toxicities (DLT) at doses significantly higher than sufficiently active ...
J. Sachs, K. Mayawala, S. Gadamsetty, S. P. Kang, D. D. de Alwis   +4 more
semanticscholar   +1 more source

Reduction of cyclophosphamide dose for patients with subset 2 low‐risk rhabdomyosarcoma is associated with an increased risk of recurrence: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group [PDF]

, 2017
David Walterhouse, Alberto S. Pappo, Jane L. Meza, John C. Breneman, Andrea Hayes‐Jordan, David M. Parham, Timothy P. Cripe, James R. Anderson, William H. Meyer, Douglas S. Hawkins   +9 more
openalex   +1 more source

Appetitive, antinociceptive, and hypothermic effects of vaped and injected Δ-9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex

, 2021
Catherine F. Moore, Catherine M. Davis, Eric L. Harvey, Michael A. Taffe, Elise M. Weerts   +4 more
openalex   +2 more sources

EPI Update, October 9, 2009 [PDF]

, 2009
Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public ...

core  

Assessing Clinical Outcomes of Metronidazole for Intra-Abdominal Infections When Dosed Every 12 h Versus Every 8 h in a Multi-Center Health System

Antibiotics
Background: Metronidazole is the preferred anaerobic agent for empiric treatment of intra-abdominal infections (IAI). Although dosed every 8 h (q8hr), blood concentrations exceed the in vitro minimum inhibitory concentration (MIC) for anaerobic organisms
Sarah Galante, Ramya Castillo, Todd Price, MaiCuc Tran, Stefanie Stramel-Stafford   +4 more
doaj   +1 more source

Comparative analysis of US real-world dosing patterns and direct infusion-related costs for matched cohorts of rheumatoid arthritis patients treated with infliximab or intravenous golimumab

ClinicoEconomics and Outcomes Research, 2019
Lorie A Ellis,1 Elisabetta Malangone-Monaco,2 Helen Varker,3 Diana Stetsovsky,3 Maureen Kubacki,1 Raphael J DeHoratius,1,4 Shelly Kafka1 1Real World Value and Evidence, Janssen Scientific Affairs, LLC, Horsham, PA, USA; 2Life Sciences, IBM Watson Health,
Ellis LA, Malangone-Monaco E, Varker H, Stetsovsky D, Kubacki M, DeHoratius RJ, Kafka S   +6 more
doaj  

Single-dose pharmacokinetics and pharmacodynamics of oral tenofovir and emtricitabine in blood, saliva and rectal tissue: a sub-study of the ANRS IPERGAY trial [PDF]

, 2016
Julien Fonsart, Sentob Saragosti, Milad Taouk, Gilles Peytavin, Lane R. Bushman, Isabelle Charreau, Allan J. Hance, Lauriane Goldwirt, Stéphane Morel, Fabrizio Mammano, Bénédicte Loze, Catherine Capitant, François Clavel, Nadia Mahjoub, Laurence Meyer, Peter L. Anderson, Constance Delaugerre, Jean‐Michel Molina   +17 more
openalex   +1 more source

The extent of unnecessary tooth loss due to extractions prior to radiotherapy based on radiation field and dose in patients with head and neck cancer [PDF]

, 2023
Doke J.M. Buurman, Caroline M. Speksnijder, Marlies Granzier, Veronique C. M. L. Timmer, Frank Hoebers, Peter Keßler   +5 more
openalex   +1 more source

Ceftaroline fosamil doses and breakpoints forStaphylococcus aureusin complicated skin and soft tissue infections [PDF]

, 2018
Shampa Das, Jianguo Li, Joseph P. Iaconis, Diansong Zhou, Gregory G. Stone, Jean Li Yan, David Melnick   +6 more
openalex   +1 more source

Regulatory T-lymphocyte subsets in children with chronic immune thrombocytopenia after high-dose of dexamethasone [PDF]

, 2022
Khalid I. Elsayh, Khaled Saad, Naglaa S. Osman, Khaled Hashim Mahmoud, Faisal Alkhateeb Ahmad, Shaimaa M. Khalaf, Noha G. Sayed, Zeinab Albadry M. Zahran, Aliaa Ghandour, Amira Elhoufey, Tamer Bedir, Asmaa M. Zahran   +11 more
openalex   +1 more source