Results 171 to 180 of about 1,146,644 (343)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Climbing the Evidence Pyramid: Dosing Considerations for Medical Cannabis in the Management of Chronic Pain

open access: yesMedical Cannabis and Cannabinoids, 2023
Sebastian Jugl   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Aripiprazole Lauroxil: Development and Evidence-Based Review of a Long-Acting Injectable Atypical Antipsychotic for the Treatment of Schizophrenia

open access: yesNeuropsychiatric Disease and Treatment
Leslie Citrome,1 Christoph U Correll,2– 6 Andrew J Cutler,7,8 Martin Dunbar,9 Amber R Hoberg,10 Craig Hopkinson,9 Gregory W Mattingly,11,12 James A McGrory,9 Bhaskar Rege,9 Peter J Weiden,13 David McDonnell14 1New York Medical College, Valhalla, NY, USA;
Citrome L   +10 more
doaj  

Much Ado about Dosing: The Needs and Challenges of Defining a Standardized Cannabis Unit

open access: yesMedical Cannabis and Cannabinoids, 2021
Sebastian Jugl   +4 more
doaj   +1 more source

Preliminary insights into artificial intelligence guided dosing in hypertension and diabetes: challenges and lessons learnt in a pilot feasibility study. [PDF]

open access: yesJAMIA Open
Sumner J   +13 more
europepmc   +1 more source

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