Results 181 to 190 of about 1,146,644 (343)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta-Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs. [PDF]

Health Sci Rep
Azami P, Hosseinpour A, Zandi E, Rajabi F, Mirhosseini A, Farhangdoust S, Attar A.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A full educational resource review of grey literature resources for vancomycin dosing tutorials. [PDF]

JAC Antimicrob Resist
Kuska ES, Mlyniec J, Wantuch KL, Brock L, Desear KE, Gauthier TP, Hirsch EB, Kufel WD, Morrisette T, Pearsall M, White BP, Carreno JJ.   +11 more
europepmc   +1 more source

Optimization and Dose Estimation of Aerosol Delivery to Non-Human Primates

, 2015
Ronan MacLoughlin, Geert van Amerongen, James B. Fink, Hettie M. Janssens, W. Paul Duprex, Rik L. de Swart   +5 more
openalex   +2 more sources

Successful Treatment with Low-dose Crizotinib in a Patient with <i>ROS1</i>-rearranged Lung Cancer Who Developed Crizotinib-induced Heart Failure

, 2022
Takahiko Hashimoto, Kosuke Takahashi, Sachiko Ota, Nobumasa Okumura, Haruka Kondo, Asuki Fukatsu, Toru Hara   +6 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Impact of dosing schedules on performance of rotavirus vaccines in Ghana

Ernest O. Asare, Mohammad A. Al‐Mamun, George Armah, Benjamin A. Lopman, Virginia E. Pitzer   +4 more
openalex   +1 more source