Results 11 to 20 of about 3,798,723 (244)

From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Clinical pharmacology and therapy, 2021
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in individual patients with infections.
S. Wicha, A. Märtson, E. Nielsen, B. Koch, L. Friberg, J. Alffenaar, Iris K. Minichmayr   +6 more
semanticscholar   +1 more source

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Clinical Infectious Diseases, 2020
Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection.
Xueting Yao, F. Ye, Miao Zhang, Cheng Cui, Baoying Huang, P. Niu, X. Liu, Li Zhao, Erdan Dong, Chunli Song, S. Zhan, R. Lu, Haiyan Li, W. Tan, Dongyang Liu   +14 more
semanticscholar   +1 more source

Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals.

Journal of the American Medical Association (JAMA), 2021
Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals Standard dosing intervals for BNT162b2 and mRNA-1273 SARSCoV-2 vaccines are 21 and 28 days, respectively.1 Data suggest improved effectiveness of ChAdOx1 adenoviral2 and other ...
B. Grunau, D. Goldfarb, Michael Asamoah-Boaheng, L. Golding, T. Kirkham, P. Demers, P. Lavoie   +6 more
semanticscholar   +1 more source

Dosing pole recommendations for lymphatic filariasis elimination: A height-weight quantile regression modeling approach [PDF]

, 2019
BACKGROUND: The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs.
Dubray, Christine, Fischer, Peter U, Goss, Charles W, Hardy, Myra, Jambulingam, Purushothaman, King, Christopher L, Laman, Moses, Lemoine, Jean Frantz, O\u27Brian, Katiuscia, Robinson, Leanne J, Samuela, Josaia, Schechtman, Kenneth B, Subramanian, Swaminathan, Supali, Taniawati, Weil, Gary J   +14 more
core   +2 more sources

Low-dose alum application trialled as a management tool for internal nutrient loads in Lake Okaro, New Zealand [PDF]

, 2008
Aluminium sulfate (alum) was applied to Lake Okaro, a eutrophic New Zealand lake with recurrent cyanobacterial blooms, to evaluate its suitability for reducing trophic status and bloom frequency.
Gibbs, Max M., Hamilton, David P., Paul, Wendy J.   +2 more
core   +2 more sources

Use of Estimating Equations for Dosing Antimicrobials in Patients with Acute Kidney Injury Not Receiving Renal Replacement Therapy. [PDF]

, 2018
Acute kidney injury (AKI) can potentially lead to the accumulation of antimicrobial drugs with significant renal clearance. Drug dosing adjustments are commonly made using the Cockcroft-Gault estimate of creatinine clearance (CLcr). The Modified Jelliffe
Awdishu, Linda, Bouchard, Josée, Chertow, Glenn M, Connor, Ana Isabel, Macedo, Etienne, Mehta, Ravindra L   +5 more
core   +2 more sources

Optimizing Guideline-Recommended Antibiotic Doses for Pediatric Infective Endocarditis [PDF]

, 2016
The American Heart Association recently published an updated scientific statement on the management of infective endocarditis in childhood. The recommendations included for vancomycin, aminoglycoside, and β-lactam dosing and monitoring are based ...
Israel, Emily N., Knoderer, Chad A., Nichols, Kristen R., Thomas, Christopher A.   +3 more
core   +3 more sources

β-Lactam Dosing in Critical Patients: A Narrative Review of Optimal Efficacy and the Prevention of Resistance and Toxicity

Antibiotics, 2022
Antimicrobial prescription in critically ill patients represents a complex challenge due to the difficult balance between infection treatment and toxicity prevention.
João Gonçalves Pereira, Joana Fernandes, Ana Rita Duarte, Susana Mendes Fernandes   +3 more
doaj   +1 more source

Practice Patterns of Treatment Strategy of Limited-Stage Small-Cell Lung Cancer: Survey of Chinese Oncologists

Frontiers in Oncology, 2022
BackgroundThoracic radiotherapy (TRT) with concurrent chemotherapy is the standard treatment of limited-stage small-cell lung cancer (LS-SCLC). However, there is still a controversy surrounding the treatment strategy especially optimal dosing and ...
Chang Xu, Meng Li, Xuwei Cai, Shuanghu Yuan, Jianzhong Cao, Shuchai Zhu, Ming Chen, Nan Bi, Xiao Hu, Jiancheng Li, Wei Zhou, Ping Wang, Lujun Zhao, Ningbo Liu   +13 more
doaj   +1 more source

Recommendation of Antimicrobial Dosing Optimization During Continuous Renal Replacement Therapy

Frontiers in Pharmacology, 2020
Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients for various indications recent years. It is still intricate for clinicians to decide a suitable empiric antimicrobial dosing for patients receiving CRRT.
Lu Li, Xin Li, Yanzhe Xia, Yanqi Chu, Hai-Li Zhong, Jia Li, Pei Liang, Yishan Bu, R. Zhao, Y. Liao, Ping Yang, Xiaoyang Lu, Saiping Jiang   +12 more
semanticscholar   +1 more source