Results 191 to 200 of about 1,146,644 (343)

A Bayesian adaptive design for cancer phase I trials using a flexible range of doses

, 2017
Mourad Tighiouart, Galen Cook‐Wiens, André Rogatko   +2 more
openalex   +2 more sources

Comparative Efficacy of Daratumumab Monotherapy and Pomalidomide Plus Low-Dose Dexamethasone in the Treatment of Multiple Myeloma: A Matching Adjusted Indirect Comparison [PDF]

, 2017
Suzy Van Sanden, Tetsuro Ito, Joris Diels, Martin Vogel, Andrew R. Belch, Albert Oriol   +5 more
openalex   +1 more source

Optimizing antenatal corticosteroid therapy for improving outcome of premature infants. [PDF]

, 2019
A Donaldson, Augusto F. Schmidt, CL Elliott, D Roberts, E Asztalos, EP Davis, F Althabe, F Waffarn, GC Liggins, GC Liggins, HG Liley, JP Vogel, Kristi L. Watterberg, M Della Torre, P Ballabh, Philip L. Ballard, PL Ballard, PL Ballard, RS Egerman, SE Tsuei   +19 more
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Review of dutasteride/tamsulosin fixed-dose combination for the treatment of benign prostatic hyperplasia: efficacy, safety, and patient acceptability

, 2011
Jack Barkin
openalex   +2 more sources

EFICIÊNCIA DE RIZÓBIOS SOB DOSES DE FÓSFORO NA CULTURA DO FEIJÃO-CAUPI [PDF]

, 2019
Evaldo Morais da Silva, Manoel Mota dos Santos, Marília Barcelos Souza Lopes, Rodrigo Ribeiro Fidélis, Weslany Silva Rocha, Weslany Silva Rocha, Aloísio Freitas Chagas Júnior   +6 more
openalex   +1 more source

Evaluation of a novel ''intelligent'' dosing system for optimizing FK 506 therapy [PDF]

, 1991
Fung, J, Gordon, R, Irish, W, Lieberman, R, McCauley, J, McMichael, J, Shapiro, R, Starzl, TE, Van Thiel, DH, Warty, VS   +9 more
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

The Nephrotoxicity of Vancomycin. [PDF]

, 2017
Farber, John L., Filippone, Edward J., Kraft, Walter K.   +2 more
core   +2 more sources