Results 201 to 210 of about 1,146,644 (343)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Comprehensive pharmacokinetic/pharmacodynamic analysis of commercially available premixed daptomycin preparations against <i>Staphylococcus aureus</i> and <i>Enterococcus</i> spp. bloodstream infections using Monte Carlo simulation in adult patients. [PDF]

JAC Antimicrob Resist
Jaime E, Yassin A, Patel RH, Bhowmick T, Farkas A.   +4 more
europepmc   +1 more source

Thermal dose and thermal isoeffect dose [PDF]

International Journal of Hyperthermia, 1989
openaire   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Population Pharmacokinetic and Pharmacodynamic Prediction for Tebipenem Pivoxil Treatment of Pediatric Shigellosis. [PDF]

Clin Transl Sci
Zhang CX, Nuzhat S, Islam MR, Bashar SJ, Das S, Amin R, Qadri F, Khanam F, Ahmed D, Pavlinac PB, Chisti MJ, Ahmed T, Arnold SLM.   +12 more
europepmc   +1 more source

[Equivalent dose or dose equivalence?].

Arhiv za higijenu rada i toksikologiju, 1994
In the Croatian language the terms denoting certain physical quantities in the field of radiation protection dosimetry lack precision. Consequently, either the English expressions or mathematical formulas are used instead. The situation is even worse as only a limited number of textbooks, reference books and professional papers are available in the ...
openaire   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Invention of VH-937, a Potent HIV-1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans [PDF]

Sing‐Yuen Sit, Yan Chen, Jie Chen, Brian L. Venables, Jacob J. Swidorski, Li Xu, Ny Sin, Richard A. Hartz, Zeyu Lin, Sharon Zhang, Zhufang Li, Dauh‐Rurng Wu, Peng Li, James Kempson, Xiaoping Hou, Yoganand Shanmugam, Dawn D. Parker, Susan Jenkins, Jean Simmermacher, Paul Falk, Brian McAuliffe, Mark I. Cockett, Umesh Hanumegowda, Ira B. Dicker, Mark Krystal, Nicholas A. Meanwell, Alicia Regueiro‐Ren   +26 more
openalex   +1 more source