Results 211 to 220 of about 1,146,644 (343)

High-dose etoposide formulations do not saturate intestinal P-glycoprotein: Development, stability, and pharmacokinetics in Sprague-Dawley rats

, 2020
Ahmed A. Abdulhussein Al-Ali, Louis Sandra, Dries Versweyveld, Ils Pijpers, Lieve Dillen, An Vermeulen, Jan Snoeys, René Holm, Carsten Uhd Nielsen   +8 more
openalex   +2 more sources

Laboratory Evaluation Of Dose And Manner Of Pickup Of Spinosad On The Migratory Grasshopper, 1995 [PDF]

, 1996
R. Nelson Foster, K. C. Reuter, Lonnie R. Black, E Kahler, B. Fulle, E. A. Flora   +5 more
openalex   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Weight-band-based simplification of oral allometric miltefosine dosing in paediatric patients with visceral leishmaniasis. [PDF]

J Antimicrob Chemother
Mazariegos Herrera A, Karlsson MO, Svensson EM, Dorlo TPC.   +3 more
europepmc   +1 more source

Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants [PDF]

, 2018
Cinzia Auriti, Bianca Maria Goffredo, Maria Paola Ronchetti, Fiammetta Piersigilli, Sara Cairoli, Iliana Bersani, Andrea Dotta, Manjunath P. Pai   +7 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Developmental effects of ±3,4‐methylenedioxymethamphetamine on spatial versus path integration learning: Effects of dose distribution

, 2007
Charles V. Vorhees, Tori L. Schaefer, Michael T. Williams   +2 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Correction to "Clinical Pharmacology Perspective on Direct-To-Subcutaneous Dosing of T Cell Engagers in Oncology First-In-Human Studies". [PDF]

Clin Transl Sci
europepmc   +1 more source

The antimetastatic effect of a single low dose of cyclophosphamide involves modulation of galectin-1 and Bcl-2 expression

, 2002
Gabriel A. Rabinovich, Natalia Rubinstein, Pablo Matar, Viviana R. Rozados, Silvia Gervasoni, Graciela Scharovsky   +5 more
openalex   +2 more sources