Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients
Clinical Infectious Diseases, 2020 Hydroxychloroquine (HCQ) appears to be a promising treatment for COVID-19. However, all ongoing clinical trials with HCQ use different dosing regimens, resulting on various concentrations PK studies are therefore needed to define the optimal dosing ...
S. Perinel +10 more
semanticscholar +1 more source
MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments [PDF]
, 2013 Background: Oral and vaginal preparations of tenofovir as pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection have demonstrated variable efficacy in men and women prompting assessment of variation in drug concentration as an ...
A Pruvost +39 more
core +5 more sources
Colistin nephrotoxicity in critically ill patients after implementation of a new dosing strategy
Journal of Infection in Developing Countries, 2019 Introduction: Intravenous colistin is increasingly used to treat multidrug-resistant Gram-negative infections. Highly variable nephrotoxicity rates have been reported.
Ayse Serra Ozel +2 more
doaj +1 more source
Robotic Exoskeleton Gait Training During Acute Stroke Inpatient Rehabilitation
Frontiers in Neurorobotics, 2020 Stroke is the leading cause of severe disability in adults resulting in mobility, balance, and coordination deficits. Robotic exoskeletons (REs) for stroke rehabilitation can provide the user with consistent, high dose repetition of movement, as well as ...
Karen J. Nolan +17 more
doaj +1 more source
Frontiers in Neurology, 2022 IntroductionThe Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy (CD PROBE) study (ClinicalTrials.gov identifier: NCT00836017), a multicenter, prospective, observational registry, was designed to identify real-world ...
Pinky Agarwal +8 more
doaj +1 more source
Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables
Frontiers in Pharmacology, 2020 The administered dose of a drug modulates whether patients will experience optimal effectiveness, toxicity including death, or no effect at all. Dosing is particularly important for diseases and/or drugs where the drug can decrease severe morbidity or ...
Rachel J. Tyson +6 more
semanticscholar +1 more source
Variations in the management of acute illness in children with congenital adrenal hyperplasia: An audit of three paediatric hospitals [PDF]
, 2018 Objective: Episodes of acute adrenal insufficiency (AI)/adrenal crises (AC) are a serious consequence of congenital adrenal hyperplasia (CAH). This study aimed to assess morbidity from acute illness in CAH and identify factors associated with use of IV ...
Allolio +25 more
core +2 more sources
Vibration-Assisted Handling of Dry Fine Powders
Actuators, 2018 Since fine powders tend strongly to adhesion and agglomeration, their processing with conventional methods is difficult or impossible. Typically, in order to enable the handling of fine powders, chemicals are added to increase the flowability and reduce ...
Paul Dunst +3 more
doaj +1 more source
Probiotics: controversial issues [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2022 Recent studies have strongly confirmed the health benefits of a variety of probiotic microorganisms. However, some issues regarding the use of probiotics currently remain unresolved or ambiguous.
Andreev V.A. +2 more
doaj +1 more source
Burosumab therapy in children with x-linked hypophosphatemia [PDF]
, 2018 BACKGROUND X-linked hypophosphatemia is characterized by increased secretion of fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently rickets, osteomalacia, and skeletal deformities.
Boot, Annemieke M +13 more
core +2 more sources