Results 51 to 60 of about 3,798,723 (244)

A bi-directional electrochemically driven micro liquid dosing system with integrated sensor/actuator electrodes [PDF]

open access: yes, 2000
In this contribution a micro liquid dosing system is presented, which allows bi-directional manipulation of fluids (i.e. pushing out and pulling in of liquids) by the electrochemical generation and removal of gas bubbles. Bi-directionality is obtained by
Bergveld, Piet   +2 more
core   +3 more sources

Initial dose of vancomycin in adult patients at a major tertiary care hospital in Saudi Arabia: A retrospective observational study

open access: yesSaudi Journal for Health Sciences, 2020
Background: Therapeutic drug monitoring is commonly performed to confirm the safe and effective use of the vancomycin; however, the facility for it is not available in many hospitals.
Sultan Mubarki   +4 more
doaj   +1 more source

Mechanical memory and dosing influence stem cell fate

open access: yesNature Materials, 2014
We investigated whether stem cells remember past physical signals and whether these can be exploited to dose cells mechanically. We found that the activation of the Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ)
Chun Yang   +3 more
semanticscholar   +1 more source

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. [PDF]

open access: yes, 2020
COR388, a small-molecule lysine-gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Arastu-Kapur, Shirin   +10 more
core   +1 more source

Dosing Cariprazine Within and Beyond Clinical Trials: Recommendations for the Treatment of Schizophrenia

open access: yesFrontiers in Psychiatry, 2022
Although the optimal dosing of an antipsychotic medication is known to be essential in the long-term management of schizophrenia, in case of novel drugs such as cariprazine, determining the right dosing strategy is not that simple.
Elmars Rancans   +3 more
doaj   +1 more source

Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety

open access: yesAntimicrobial Agents and Chemotherapy, 2019
Linezolid is administered as a fixed dose to all patients despite evidence of increased exposure and myelosuppression in renal impairment. The objectives of these studies were to assess the risk of thrombocytopenia with standard-dose linezolid in renal ...
R. Crass, P. Cojutti, M. Pai, F. Pea
semanticscholar   +1 more source

A New Method for Exposing Deposit Feeders to Contaminated Sediments for Food Chain Studies [PDF]

open access: yes, 2017
(excerpt) The ubiquity and refractory nature of certain organic compounds, such as chlorinated pesticides and polychlorinated biphenyls (PCB\u27s), results in their accumulation in aquatic sediments (Holdrinet et al. 1978, Peck et al.
Meier, Peter G, Roberts, Dale
core   +3 more sources

Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma

open access: yesMolecules, 2020
Plant secondary metabolites have been seen as alternatives to seeking new medicines for treating various diseases. Phytochemical scientists remain hopeful that compounds isolated from natural sources could help alleviate the leading problem in oncology ...
Win Sen Heng, Shiau-Chuen Cheah
doaj   +1 more source

Impact of Removing Race Coefficient from Glomerular Filtration Rate Estimation Equations on Antidiabetics Among Black Patients

open access: yesPharmacy
Background: In 2021, the National Kidney Foundation–American Society of Nephrology (NKF-ASN) recommended the use of the 2021 refit equation without race; however, the effect of the removal is unclear.
Dhakrit Rungkitwattanakul   +8 more
doaj   +1 more source

Immunologic Dose-Response to Adenovirus-Vectored Vaccines in Animals and Humans: A Systematic Review of Dose-Response Studies of Replication Incompetent Adenoviral Vaccine Vectors when Given via an Intramuscular or Subcutaneous Route

open access: yesVaccines, 2020
Optimal vaccine dosing is important to ensure the greatest protection and safety. Analysis of dose-response data, from previous studies, may inform future studies to determine the optimal dose.
Sara Afrough   +4 more
doaj   +1 more source

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