Results 61 to 70 of about 3,798,723 (244)

Evaluation of dosing strategy for pembrolizumab for oncology indications

Journal of Immunotherapy for Cancer, 2017
BackgroundTraditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
T. Freshwater, A. Kondic, M. Ahamadi, Claire H. Li, R. de Greef, D. D. de Alwis, J. Stone   +6 more
semanticscholar   +1 more source

The wide variety of methotrexate dosing regimens for the treatment of atopic dermatitis: a systematic review

Journal of Dermatological Treatment
Background:Methotrexate is an off-label therapy for atopic dermatitis. A lack of consensus on dosing regimens poses a risk of underdosing and ineffective treatment or overdosing and increased risk of side effects.
Anouk G. M. Caron, Manja Bloem, Hajar El Khattabi, Ayla C. de Waal, Astrid M. van Huizen, Nerissa P. Denswil, Louise A. A. Gerbens, Phyllis I. Spuls   +7 more
doaj   +1 more source

Iron deficiency anemia in males: a dosing dilemma?

Journal of Community Hospital Internal Medicine Perspectives, 2021
Introduction: Iron deficiency anemia is a major problem worldwide treated by replenishment of iron stores. The treatment is complicated by differing pharmacodynamics of administrative routes, equations with design effects, ongoing losses, additional ...
Abu Baker Sheikh, Nismat Javed, Zainab Ijaz, Venus Barlas, Rahul Shekhar, Blavir Rukov   +5 more
doaj   +1 more source

No Time Dependence of Ciprofloxacin Pharmacokinetics in Critically Ill Adults: Comparison of Individual and Population Analyses

Pharmaceutics, 2021
The aim of this prospective PK study was to evaluate the pharmacokinetics of ciprofloxacin dosed within the first 36 h (early phase) and after 3 days of treatment (delayed phase) using individual and population PK analysis. The secondary aim of the study
Martin Šíma, Danica Michaličková, Pavel Ryšánek, Petra Cihlářová, Martin Kuchař, Daniela Lžičařová, Jan Beroušek, Jan Miroslav Hartinger, Tomáš Vymazal, Ondřej Slanař   +9 more
doaj   +1 more source

Pre-hospital management of acute Addison’s Disease – Audit of patients attending a referral hospital in a regional area [PDF]

, 2019
Context: Adrenal crises (AC) cause morbidity and mortality in patients with Addison’s disease [primary adrenal insufficiency (PAI)]. Patient-initiated oral stress dosing, with parenteral hydrocortisone, is recommended to avert ACs. While these should be
Goubar, Thomas, McGrath, Shaun, Rushworth, R Louise, Torpy, David J   +3 more
core   +1 more source

Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children [PDF]

, 2008
BackgroundCombination therapies are frequently recommended as maintenance therapy for people with asthma, whose disease is not adequately controlled with inhaled steroids.
Aalbers, Aalbers, Aalbers, Aalbers, Adachi, Adams, Adams, Alonso, Ambrose, Becker, Bleecker, Bleecker, Bleecker, Bleecker, Bousquet, Bousquet, Bousquet, Brambilla, Buhl, Cates, Cates, Cazzola, Chuchalin, Creemers, D'Urzo, Dahl, Dahl, Dahl, Edwards, Fitzgerald, FitzGerald, Gibson, Greenstone, Hampel, Hampel Jr, Higgins, Higgins, Jenkins, Jenkins, Johansson, Kaik, Kuna, Lee, Lee, Lee, Lundback, Lötvall, Martin, Miller, Molimard, Ni Chroinin, Noord, O'Connor, Palmqvist, Palmqvist, Price, Price, Price, Ringdal, Ringdal, Suissa, Vogelmeier, Walters, Welte, Williams   +64 more
core   +1 more source

Effect of Enfortumab Vedotin Dose Adjustment on Efficacy in Metastatic Urothelial Carcinoma: A Retrospective Single-Center Experience 

Cancer Management and Research, 2023
Anna Clennon,1 Megan Hinkley,1 Kristen Nymberg,1 Lauren Ledbetter,1 Demond Handley,2 Eric McLaughlin,2 Amir Mortazavi,3 Katharine A Collier3 1Department of Pharmacy, the James Cancer Hospital at the Ohio State University, Columbus, OH, USA; 2Department ...
Clennon A, Hinkley M, Nymberg K, Ledbetter L, Handley D, McLaughlin E, Mortazavi A, Collier KA   +7 more
doaj  

Disease Flare and Reactogenicity in Patients With Rheumatic and Musculoskeletal Diseases Following Two‐Dose SARS–CoV‐2 Messenger RNA Vaccination [PDF]

, 2021
Caoilfhionn M Connolly, Jake A. Ruddy, Brian J. Boyarsky, Iulia Barbur, William A. Werbel, Duvuru Geetha, Jacqueline Garonzik‐Wang, Dorry L. Segev, Lisa Christopher‐Stine, Julie J. Paik   +9 more
openalex   +1 more source

Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. [PDF]

, 2017
A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily,
Bloedon, LeAnne T., Duffy, Danielle, Dunbar, Richard L., Fogelman, Alan M., Movva, Rajesh, Navab, Mohamad, Norris, Robert B., Rader, Daniel J.   +7 more
core   +2 more sources

Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories

Frontiers in Pharmacology, 2022
There is limited understanding regarding kratom use among US adults. Although motivations for use are increasingly understood, typical kratom doses, threshold of (low and high) doses for perceived effectiveness, and effects produced during cessation are ...
Kirsten E. Smith, Jeffrey M. Rogers, Kelly E. Dunn, Oliver Grundmann, Christopher R. McCurdy, Destiny Schriefer, David H. Epstein   +6 more
doaj   +1 more source