Results 91 to 100 of about 155,014 (298)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Information Processing Biases and Attachment Styles in Adolescents with Dissociative Disorders

open access: yesIndian Journal of Psychological Medicine
Background: Dissociative disorders invade and interfere with the person’s continuity of normal psychological functioning and exhibit slower or impaired processing of threat-related information and attachment styles play a significant role in their ...
Ritwika Nag   +2 more
doaj   +1 more source

Working memory load elicits attentional bias to threat [PDF]

open access: yes, 2014
Anxious individuals tend to show attentional bias to threats and dangers; this is usually in-terpreted as a specific bias in threat-processing. However, they also tend to show general working memory and cognitive control impairments. We hypothesised that
Booth, Robert, Sharma, Dinkar
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Cognitive bias measurement and social anxiety disorder: Correlating self-report data and attentional bias

open access: yesInternet Interventions, 2015
Social anxiety disorder (SAD) and attentional bias are theoretically connected in cognitive behavioral therapeutic models. In fact, there is an emerging field focusing on modifying attentional bias as a stand-alone treatment.
Alexander Miloff   +2 more
doaj   +1 more source

Learned predictiveness acquired through experience prevails over the influence of conflicting verbal instructions in rapid selective attention. [PDF]

open access: yesPLoS ONE, 2018
Previous studies have provided evidence that selective attention tends to prioritize the processing of stimuli that are good predictors of upcoming events over nonpredictive stimuli.
Pedro L Cobos   +3 more
doaj   +1 more source

Eye gaze markers indicate visual attention to threatening images in individuals with chronic back pain [PDF]

open access: yes, 2018
Research into attentional biases and threatening, pain-related information has primarily been investigated using reaction time as the dependent variable.
Beck, Cohen, Eysenck, Kugler, Lang
core   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

The role of anterior cingulate cortex in the affective evaluation of conflict [PDF]

open access: yes, 2017
An influential theory of anterior cingulate cortex (ACC) function argues that this brain region plays a crucial role in the affective evaluation of performance monitoring and control demands.
Braem, Senne   +5 more
core   +2 more sources

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