Results 201 to 210 of about 1,671,076 (389)
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena +11 morewiley +1 more sourceRandomized Double Blind Controlled Study Comparing Vecuronium Priming, Magnesium Pretreatment and Combination of the Two Methods on the Onset of Intubating Conditions
, 2015 Shazia Ambareen, G Tarbeeh, M Othman, H Sang, Y Keum, T Ki, H Wu, T Ye, L Sun, M Rao, A Venkataraman, R Malleswari, J Schmidt, A Irouschek, T Muenster, T Hemmerling, S Albrecht, M Kim, A Oh, Y Jeon, J Hwang, S Do, Feldman Stanley, C Czarnetzki, C Lysakowski, N Elia, M Tramer, H Dale, S Park, Y Cho, J Oh, J Hwang, M Bock, L Haselmann, B Bttiger, J Motsch +35 moreopenalex +1 more sourceA double-blind, randomized clinical trial of the effect of ω-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition
European Journal of Clinical Nutrition, 2010 M. Skouroliakou, D. Konstantinou, Katerina Koutri, Christina, Kakavelaki, Maria Stathopoulou, Marina Antoniadi, Nikolaos Xemelidis, Victoria Kona, Markantonis Sophia +9 moresemanticscholar +1 more sourceIGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response
Advanced Science, EarlyView.IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang +9 morewiley +1 more sourceUfmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis
Advanced Science, EarlyView.DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin +16 morewiley +1 more sourceMirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial
Irene J Higginson, Sarah T Brown, Adejoke O Oluyase, Peter May, Matthew Maddocks, Massimo Costantini, Sabrina Bajwah, Charles Normand, Claudia Bausewein, Steffen T. Simon, Karen Ryan, David C. Currow, Miriam J. Johnson, Simon P. Hart, H M Mather, Małgorzata Krajnik, Silvia Tanzi, Luca Ghirotto, Charlotte E. Bolton, Piotr Janowiak, Elena Turola, Caroline J. Jolley, Geraldine Murden, Andrew Wilcock, Bobbie Farsides, Julia Brown, Emer Kelly, Mirco Lusuardi, Giovanni Gambassi, Ewa Jassem, Kathrin Kahnert, Caitlin Sheehan, Peter Eastman, Michael Epton, Courtney Coleman, Belinda S Fazakas, Debs Smith +36 moreopenalex +1 more sourceIntestinal-level anti-inflammatory bioactivities of catechin-rich green tea: Rationale, design, and methods of a double-blind, randomized, placebo-controlled crossover trial in metabolic syndrome and healthy adults
, 2019 Joanna K. Hodges, Jiangjiang Zhu, Zhongtang Yu, Yael Vodovotz, Guy Brock, Geoffrey Y. Sasaki, Priyankar Dey, Richard S. Bruno +7 moreopenalex +1 more sourceRandomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.
American Journal of Psychiatry, 2006 T. McGlashan, R. Zipursky, D. Perkins, J. Addington, T. Miller, S. Woods, K. Hawkins, R. Hoffman, Adrian Preda, I. Epstein, D. Addington, S. Lindborg, Q. Trzaskoma, M. Tohen, A. Breier +14 moresemanticscholar +1 more source
