Results 101 to 110 of about 2,222,944 (354)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Qualifying Recital: Greg Garcia, double bass

open access: yes, 2008
Mr. Garcia is a student of Paul EllisonSonata in A Minor, Telemann -- Ode d'Espagne, François Rabbath -- Thanatos, Rabbath -- Concerto No. 1 in B Minor, Giovanni Bottesini -- Sonata for Double Bass and Piano, Hindemith -- Nomos, David Koblitz -- Soli II

core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Adoption and diffusion of double entry book-keeping in Mexico and Spain: A related but under-investigated development

open access: yes
There is a consensus within Mexican accounting historiography regarding widespread use of double entry bookkeeping by the end of the 19th Century in the realm of both private and public enterprise.
Maixe-Altes, J. Carles   +3 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

E-Commerce Activities Carried Out by Natural Persons. Accounting and Tax Treatment

open access: yesCECCAR Business Review
Nowadays, more and more Romanians do their shopping online, accessing various websites where individual persons/legal entities display the products they want to sell.
Elena STĂNCIULESCU
doaj   +1 more source

THE BIOGRAPHY OF JÁNOS NAGYVÁTHY - THE FIRST HUNGARIAN AGRICULTURAL WRITER [PDF]

open access: yesJournal of Central European Agriculture, 2002
210 years ago Nagyváthy János published the first systematic, agricultural trade book, called ’Diligent Farmers’ in Hungarian in Pest. This outstanding person of our agricultural history was born on 19th January 1755, in Miskolc.
Gábor LUKÁCS, Judit LUKÁCSNÉ PETŐ
doaj  

Vertical Product Differentiation, Entry-Deterrence Strategies, and Entry Qualities [PDF]

open access: yes
We analyze the potential entry of a new product into a vertically differentiated market. Here the entry-deterrence strategies of the incumbent firm rely on モlimit qualities.ヤ The model assumes quality-dependent marginal production costs and considers
Moschini, GianCarlo, Noh, Yong-Hwan
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

ORGANIZING SINGLE ENTRY ACCOUNTING, IN AN AUTHORIZED NATURAL PERSON. CASE STUDY [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2017
In this paper it is showed how to implement the single entry accounting system with a case study in a P.F.A. (authorized natural person) in Călăraşi county, which has as main activity: “Growing of cereals (except rice), of vegetables and plants producing
Daniela CREŢU
doaj  

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