Results 91 to 100 of about 1,061,792 (286)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Latest results from Double Chooz

, 2017
Double Chooz is a short-baseline neutrino disappearance experiment. It detects ν̄e produced in the power plant of Chooz, France, where is located. The main goal of the experiment is the measurement of θ13 mixing angle and in 2011 for the first time the ...
Minotti A., Double Chooz collaboration
core   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Determinants of adoption of grafted avocado (Persea americana Miller) varieties from bure and Jabitehnan districts, west Gojjam zone, Ethiopia

Discover Food
Avocado fruits provide a significant nutritional and economic benefit for rural households; however, the factors that influence adoption of grafted avocado varieties and the intensity of adoption require further investigation in the study area. The study
Gizachew Wosene, Wubalem Gobie, Wondye Mengistu, Tegbew Walle, Asrebeb Sahle   +4 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A double hurdle approach for company further training behaviour and an empirical test of this using data from the IAB establishment panel [PDF]

"In this paper the further training behaviour of firms is explained using a double hurdle approach: the first hurdle is that the further training of employees is worthwhile for the firms in general, the second hurdle is that demand for further training ...
Kohaut, Susanne, Neubäumer, Renate
core  

Market participation intensity of smallholder farmers in the Northern Region of Ghana

Discover Agriculture
Smallholder farmers’ market participation is challenged by transaction expenses and limited by market access because of the low potential for maximising yield from production.
Adam Iddrisu, Paul Kwame Nkegbe, Franklin N. Mabe   +2 more
doaj   +1 more source

Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness

Advanced Science, EarlyView.
Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu, Qin Su, Cheng Guan, Biwang Pan, Wenjie Hu, Jun Yan, Yifan Feng, Longcheng Tang, Xuewu Huang, Jiefeng Gao, Wancheng Gu   +10 more
wiley   +1 more source

MODELING FRESH ORGANIC PRODUCE CONSUMPTION: A GENERALIZED DOUBLE-HURDLE MODEL APPROACH

Using actual retail data, this study is intended to profile consumers' social economic characteristics related to the growth of the fresh organic produce market with a generalized double-hurdle model.
Huang, Chung L., Lin, Biing-Hwan, Zhang, Feng   +2 more
core   +1 more source